Journal of the American Chemical Society p. 2998 - 3017 (1990)
Update date:2022-08-04
Topics:
Jones
Reamer
Desmond
Mills
Details of model studies probing the chemistry of the tricarbonyl region of FK-506 are presented, and their use in designing a successful route to this immunosuppressant is outlined. Application of asymmetric oxazolidinone alkylation/aldol methodology to a convergent, highly flexible synthesis of the C10-C18 fragment and to improvements in the preparation of the C20-C34 segment are also discussed.
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