Synthetic Communications p. 451 - 458 (2011)
Update date:2022-08-03
Topics:
Marjani, Katayoun
Khalesi, Maryam
Ashouri, Akram
Jalali, Aazam
Ziyaei-Halimehjani, Azim
Michael addition of thioacetic and thiobenzoic acids to activated olefins was investigated in the presence of water under catalyst-free conditions. This process, in addition to being green, has an excellent yield. With simple filtration, high-quality products were obtained on a large scale. Competitive dithiane formation and ester cleavage were not observed. Also, excellent yield was obtained using this simple process for the final step of spironolactone synthesis.
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