Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XI: Oligoamines with two primary amino groups

Article abstract of DOI:10.1002/ardp.19903230210

Ten branched α,ω-alkanediamines with two primary amino groups have been synthesized and tested for their antiplatelet and anticoagulant effects. Seven of them inhibited the platelet aggregation induced by collagen at an IC₅₀ ranging from 5-11 μmol/L. In concentrations up to 400 μmol/L the one stage thromboplastin time was only slightly prolonged (Δt < 7s).