In vivo intracerebral microdialysis studies in rats of MPP+ analogues and related charged species

DOI: 10.1021/jm00170a029

Source and publish data:

Journal of Medicinal Chemistry p. 2221 - 2230 (1990)

Update date:2022-08-04

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Authors:

Rollema Rollema

Johnson Johnson

Booth Booth

Caldera Caldera

Lampen Lampen

Youngster

Trevor Trevor

Naiman Naiman

Castagnoli Jr.

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Article abstract of DOI:10.1021/jm00170a029

The in vivo dopaminergic neurotoxic properties of 45 MPTP and MPP⁺ analogues and related compounds were examined by an intrastriatal microdialysis assay in conscious rats. MPP⁺-like toxicity, as evidenced by the irreversible effects

Full text of DOI:10.1021/jm00170a029

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