Stereoselective Reduction of α-Cyclopropyl Ketones and α-Cyclopropyl Aldols. Stereo-directing Effect by α-Trimethylsilyl Group

DOI: 10.1016/S0040-4039(01)80590-6

Source and publish data:

Tetrahedron Letters p. 5447 - 5450 (1989)

Update date:2022-07-31

Topics: -Reduction

Authors:

Shimazaki, Masato

Hara, Hisaaki

Suzuki, Keisuke

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Article abstract of DOI:10.1016/S0040-4039(01)80590-6

Stereoselective reduction of α-chiral α-cyclopropyl ketones and α-cyclopropyl aldols is described.Introduction of trimethylsilyl (TMS) group to the α-position of cyclopropyls leads to virtually complete stereoselection to give the stereo-defined β-cyclopr

Full text of DOI:10.1016/S0040-4039(01)80590-6

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