TOTAL SYNTHESIS OF HALICHONDRINS: HIGHLY STEREOSELECTIVE CONSTRUCTION OF A HOMOCHIRAL PENTASUBSTITUTED H-RING PYRAN INTERMEDIATE FROM α-D-GLUCOSE

Article abstract of DOI:10.1016/S0040-4039(01)93872-9

The functionality of α-D-Glucose is stereoselectively manipulated exploiting pyranose <*> furanose <*> pyranose interconversions and lactonization for selective masking to achieve a stereocontrolled synthesis of the densely substituted H-ring pyran of halichondrins.