Inhibition of Human Leukocyte Elastase. 2. Inhibition by Substituted Cephalosporin Esters and Amides

DOI: 10.1021/jm00171a029

Source and publish data:

Journal of Medicinal Chemistry p. 2522 - 2528 (1990)

Update date:2022-08-03

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Authors:

Finke, Paul E.

Ashe, Bonnie M.

Knight, Wilson B.

Maycock, Alan L.

Navia, Manuel A.

et al. et al.

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Article abstract of DOI:10.1021/jm00171a029

A variety of 7α-methoxycephalosporin ester and amide sulfones were prepared and tested to determine the structure-activity relations for inhibition of human leukocyte elastase (HLE), a serine protease which has been implicated in several degenerative lung

Full text of DOI:10.1021/jm00171a029

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