Monocyclic β-lactam inhibitors of human leukocyte elastase

DOI: 10.1016/S0040-4020(01)82006-8

Source and publish data:

Tetrahedron p. 2255 - 2262 (1990)

Update date:2022-07-29

Topics:

Authors:

Firestone

Barker Barker

Pisano Pisano

Ashe Ashe

Dahlgren

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Article abstract of DOI:10.1016/S0040-4020(01)82006-8

Two types of monocyclic azetidinones have been synthesized that were designed to inactivate human leukocyte elastase (HLE) in three steps: first, acylation of active-site serine; second, creation of a powerful new electrophilic center; third, covalent cap

Full text of DOI:10.1016/S0040-4020(01)82006-8

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