Design, synthesis, and in vitro evaluation of novel aminomethyl-pyridines as DPP-4 inhibitors

DOI: 10.1021/ml100200c

Source and publish data:

ACS Medicinal Chemistry Letters p. 530 - 535 (2010)

Update date:2022-08-02

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Authors:

Kaczanowska, Katarzyna

Wiesmueller, Karl-Heinz

Schaffner, Arnaud-Pierre

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Article abstract of DOI:10.1021/ml100200c

A collection of novel aminomethyl-pyridines was designed, synthesized, and investigated as potential inhibitors of DPP-4. Optimization of the screening hit afforded a number of 5-aminomethyl-pyridines with inhibitory activity in the nanomolar range. Selec

Full text of DOI:10.1021/ml100200c

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