
Journal of the Chemical Society. Chemical communications p. 677 - 679 (1990)
Update date:2022-09-26
Topics:
Shen, Gwo-Jenn
Wang, Yi-Fong
Bradshaw, Curt
Wong, Chi-Huey
A new NAD-dependent alcohol dehydrogenase isolated from a Pseudomonas species catalysed the reduction of many acyclic ketones to optically active alcohols with very high enantioselectivity (90 to >98percent enantiomeric excess); the stereochemical course of the reduction was determined to be the transfer of the pro-(R) hydrogen from NADH to the Si face of the carbonyl group, a process different from that for other known alcohol dehydrogenases.
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