p-Methoxybenzyl as a New N3-Imide Protecting Group of 5-Fluorouridine and Its Application to the Synthesis of 5'-O-Acryloyl-5-fluorouridine

DOI: 10.1246/cl.1990.339

Source and publish data:

Chemistry Letters p. 339 - 342 (1990)

Update date:2022-09-26

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Authors:

Akiyama, Takahiko

Kumegawa, Masahiro

Takesue, Yasuhiro

Nishimoto, Hiroyuki

Ozaki, Shoichiro

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Article abstract of DOI:10.1246/cl.1990.339

5'-O-Acryloyl-5-fluorouridine was prepared by use of p-methoxybenzyl (PMB) group as a new N³-imide protecting group of 5-fluorouridine.A chemoselective method for protection has been developed by use of ethyldiisopropylamine as a base and depro

Full text of DOI:10.1246/cl.1990.339

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