Welcome to LookChem.com Sign In|Join Free
  • or

489-32-7

Post Buying Request

489-32-7 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
Best Selling Epimedium Extract 98% Icariin
Cas No: 489-32-7
USD $ 1.0-1.0 / Gram 10 Gram 500 Kilogram/Month Shaanxi Greenyo Biotech Co., Ltd. Contact Supplier
Epimedium extract - icariin 10%
Cas No: 489-32-7
No Data 1 Kilogram 1000 Kilogram/Month Hanzhong TRG Biotech Co.,Ltd. Contact Supplier
Epimedium Extract Icariin
Cas No: 489-32-7
USD $ 430.0-450.0 / Kilogram 1 Kilogram 100 Metric Ton/Month Salus Nutra Inc Contact Supplier
Herbal Extract 10:1 20:1 Maca Root Black Maca Extract Powder
Cas No: 489-32-7
No Data 1 Kilogram 2000 Kilogram/Month XI AN FORTA CHEM CO.,LTD Contact Supplier
Epimedium Grandiflorum Extract 489-32-7
Cas No: 489-32-7
USD $ 65.0-70.0 / Kilogram 1 Kilogram 300 Metric Ton/Month Weihai Moochun Bio-Tech Co., Ltd. Contact Supplier
EpimediumGrandiflorum Extract Icariin
Cas No: 489-32-7
USD $ 32.0-32.0 / Kilogram 1 Kilogram 300 Kilogram/Month Greenutra Resource Inc Contact Supplier
Icariin
Cas No: 489-32-7
No Data 20 Milligram ask for detail Metric Ton/Day Chengdu Herbpurify Co., Ltd Contact Supplier
Icariin
Cas No: 489-32-7
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High purity Various Specifications Icariin CAS:489-32-7
Cas No: 489-32-7
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Icariin 98% CAS 489-32-7 competitive price
Cas No: 489-32-7
USD $ 200.0-3500.0 / Kilogram 1 Kilogram 4000 Metric Ton/Day Kono Chem Co.,Ltd Contact Supplier

489-32-7 Usage

Uses

hepatoprotective

Chemical Properties

Light yellow to yellow solid

References

[1] K. M. Chen, B. F. Ge, H. P. Ma, X. Y. Liu, M. H. Bai, Y, Wang (2005) Icariin, a flavonoid from the herb Epimedium enhances the osteogenic differentiation of rat primary bone marrow stromal cells, 60, 939-942
[2] Patent CN 1199647C “Application of icariin in preparation of medicine for preventing and treating sexual dysfunction”
[3] Patent CN 104739851 A “New application of icariin, or icariin derivatives or icariin salt”

Description

Icariin is one of the major flavonoids of the herb Epimedium, which has long been used in Tranditional Chinese Medicine to treat bone fracture and prevent osteoporosis. Research has shown that icariin should be an effective component for the bone-strengthening activity of the herb Epimedium, and one of the possible mechanisms for this activity is to stimulate the proliferation and enhance the osteogenic differentiation of marrow stromal cells. Icariin is reported to prevent and treat sexual dysfunction related diseases and improve the use of vasoconstriction. Icariin is used to prepare angiotensin converting enzyme inhibitor medicines, which can be used to treat hypertension-complicated coronary diseases.
InChI:InChI=1/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1

489-32-7 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (I0862)  Icariin  >96.0%(HPLC) 489-32-7 1g 1,590.00CNY Detail
TCI America (I0862)  Icariin  >96.0%(HPLC) 489-32-7 200mg 550.00CNY Detail

489-32-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name icariin

1.2 Other means of identification

Product number -
Other names ICARRIN

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:489-32-7 SDS

489-32-7Synthetic route

3-O-(2′′′′,3′′′′,4′′′′-tri-O-acetyl-α-L-rhamnopyranosyl)-7-O-(2′′′,3′′′,4′′′,6′′′-tetra-O-acetyl-β-D-glucopyranosyl)icaritin

3-O-(2′′′′,3′′′′,4′′′′-tri-O-acetyl-α-L-rhamnopyranosyl)-7-O-(2′′′,3′′′,4′′′,6′′′-tetra-O-acetyl-β-D-glucopyranosyl)icaritin

icariin
489-32-7

icariin

Conditions
ConditionsYield
With ammonia In methanol at 20℃; for 3h;94%
UDP-glucose
133-89-1

UDP-glucose

icariside II
113558-15-9

icariside II

icariin
489-32-7

icariin

Conditions
ConditionsYield
With 7-O-glucosyltransferase from Epimedium pseudowushanense In dimethyl sulfoxide at 30℃; for 12h; pH=7.4; Kinetics; Catalytic behavior; Reagent/catalyst; Temperature; pH-value; Green chemistry; Enzymatic reaction; regiospecific reaction;32.8%
7-(benzyloxy)-5-hydroxy-3-(methoxymethoxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4Hchromen-4-one

7-(benzyloxy)-5-hydroxy-3-(methoxymethoxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4Hchromen-4-one

icariin
489-32-7

icariin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
2: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
3: silver carbonate / chloroform; N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve; Darkness; Inert atmosphere
4: silver(l) oxide / dichloromethane / 32 h / Molecular sieve; Inert atmosphere
5: ammonia / methanol / 3 h / 20 °C
View Scheme
7-(benzyloxy)-3,5-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

7-(benzyloxy)-3,5-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

icariin
489-32-7

icariin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
2: silver carbonate / chloroform; N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve; Darkness; Inert atmosphere
3: silver(l) oxide / dichloromethane / 32 h / Molecular sieve; Inert atmosphere
4: ammonia / methanol / 3 h / 20 °C
View Scheme
icaritin
118525-40-9

icaritin

icariin
489-32-7

icariin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: silver carbonate / chloroform; N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve; Darkness; Inert atmosphere
2: silver(l) oxide / dichloromethane / 32 h / Molecular sieve; Inert atmosphere
3: ammonia / methanol / 3 h / 20 °C
View Scheme
7-(benzyloxy)-3,5-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

7-(benzyloxy)-3,5-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

icariin
489-32-7

icariin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C
2: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C
3: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere
4: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
5: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
6: silver carbonate / chloroform; N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve; Darkness; Inert atmosphere
7: silver(l) oxide / dichloromethane / 32 h / Molecular sieve; Inert atmosphere
8: ammonia / methanol / 3 h / 20 °C
View Scheme
3,5,7-triacetoxy-2-(4-acetoxy-phenyl)-chromen-4-one
16274-11-6

3,5,7-triacetoxy-2-(4-acetoxy-phenyl)-chromen-4-one

icariin
489-32-7

icariin

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: potassium iodide; potassium carbonate / acetone
2: dimethyl sulfate; potassium carbonate / acetone
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C
4: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C
5: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere
6: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
7: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
8: silver carbonate / chloroform; N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve; Darkness; Inert atmosphere
9: silver(l) oxide / dichloromethane / 32 h / Molecular sieve; Inert atmosphere
10: ammonia / methanol / 3 h / 20 °C
View Scheme
7-(benzyloxy)-5-hydroxy-3-(methoxymethoxy)-2-(4-methoxyphenyl)-4H-chromen-4-one

7-(benzyloxy)-5-hydroxy-3-(methoxymethoxy)-2-(4-methoxyphenyl)-4H-chromen-4-one

icariin
489-32-7

icariin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C
2: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere
3: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
4: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
5: silver carbonate / chloroform; N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve; Darkness; Inert atmosphere
6: silver(l) oxide / dichloromethane / 32 h / Molecular sieve; Inert atmosphere
7: ammonia / methanol / 3 h / 20 °C
View Scheme
kaempferol
520-18-3

kaempferol

icariin
489-32-7

icariin

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: pyridine
2: potassium iodide; potassium carbonate / acetone
3: dimethyl sulfate; potassium carbonate / acetone
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C
5: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C
6: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere
7: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
8: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
9: silver carbonate / chloroform; N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve; Darkness; Inert atmosphere
10: silver(l) oxide / dichloromethane / 32 h / Molecular sieve; Inert atmosphere
11: ammonia / methanol / 3 h / 20 °C
View Scheme
2-(4-acetoxyphenyl)-7-(benzyloxy)-4-oxo-4H-chromene-3,5-diyl diacetate

2-(4-acetoxyphenyl)-7-(benzyloxy)-4-oxo-4H-chromene-3,5-diyl diacetate

icariin
489-32-7

icariin

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: dimethyl sulfate; potassium carbonate / acetone
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C
3: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C
4: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere
5: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
6: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
7: silver carbonate / chloroform; N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve; Darkness; Inert atmosphere
8: silver(l) oxide / dichloromethane / 32 h / Molecular sieve; Inert atmosphere
9: ammonia / methanol / 3 h / 20 °C
View Scheme
7-(benzyloxy)-3-(methoxymethoxy)-2-(4-methoxyphenyl)-5-((3-methylbut-2-en-1-yl)oxy)-4Hchromen-4-one

7-(benzyloxy)-3-(methoxymethoxy)-2-(4-methoxyphenyl)-5-((3-methylbut-2-en-1-yl)oxy)-4Hchromen-4-one

icariin
489-32-7

icariin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere
2: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
3: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
4: silver carbonate / chloroform; N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve; Darkness; Inert atmosphere
5: silver(l) oxide / dichloromethane / 32 h / Molecular sieve; Inert atmosphere
6: ammonia / methanol / 3 h / 20 °C
View Scheme
C39H48O19

C39H48O19

icariin
489-32-7

icariin

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 50℃; for 0.333333h; Temperature;6 mg
icariin
489-32-7

icariin

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
With water; sodium acetate; cellulase In ethanol; water; dimethyl sulfoxide at 37℃; pH=5.0;100%
With cellulase
Multi-step reaction with 2 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
View Scheme
icariin
489-32-7

icariin

icariside II
113558-15-9

icariside II

Conditions
ConditionsYield
With Cunninghamella blakesleana In methanol for 120h; Microbiological reaction; regioselective reaction;95.1%
With cellulase In dimethyl sulfoxide at 37℃; pH=5.7; Enzymatic reaction;84%
With β-glucanase; sodium acetate In aq. buffer at 50℃; for 5h; Enzymatic reaction;79%
icariin
489-32-7

icariin

3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-9,10-dihydro-8H-pyrano[2,3-f]chromen-4-one
38226-86-7

3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-9,10-dihydro-8H-pyrano[2,3-f]chromen-4-one

Conditions
ConditionsYield
With sulfuric acid; water In methanol for 2h; Reflux;86%
With sulfuric acid; water In 1,4-dioxane for 24h; Reflux;23%
icariin
489-32-7

icariin

3-hydroxy-7-O-β-glucose-8-prenyl-4'-methoxychrysin
56725-99-6

3-hydroxy-7-O-β-glucose-8-prenyl-4'-methoxychrysin

Conditions
ConditionsYield
With sulfuric acid In ethanol; water at 50℃; for 24h;60%
With rhamnosidase In aq. phosphate buffer at 60℃; for 24h; pH=6.8; Enzymatic reaction;1.3 g
With sulfuric acid In ethanol; water at 50℃; for 24h;450 mg
icariin
489-32-7

icariin

sodium ((2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-((5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxytetrahydro-6-methyl-2H-pyran-2-yl)oxy)-4H-chromen-7-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl sulfate

sodium ((2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-((5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxytetrahydro-6-methyl-2H-pyran-2-yl)oxy)-4H-chromen-7-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl sulfate

Conditions
ConditionsYield
With pyridine; sulfur trioxide pyridine complex Inert atmosphere;22%
acetic anhydride
108-24-7

acetic anhydride

icariin
489-32-7

icariin

3-O-(2′′′′,3′′′′,4′′′′-tri-O-acetyl-α-L-rhamnopyranosyl)-7-O-(2′′′,3′′′,4′′′,6′′′-tetra-O-acetyl-β-D-glucopyranosyl)icaritin

3-O-(2′′′′,3′′′′,4′′′′-tri-O-acetyl-α-L-rhamnopyranosyl)-7-O-(2′′′,3′′′,4′′′,6′′′-tetra-O-acetyl-β-D-glucopyranosyl)icaritin

Conditions
ConditionsYield
Stage #1: icariin With triethylamine In N,N-dimethyl-formamide for 0.166667h; Cooling with ice;
Stage #2: acetic anhydride In N,N-dimethyl-formamide for 6h; Cooling with ice;
15%
1,6,8-trihydroxy-3-methyl-9,10-anthraquinone
518-82-1

1,6,8-trihydroxy-3-methyl-9,10-anthraquinone

icariin
489-32-7

icariin

A

anthraglycoside B
23313-21-5

anthraglycoside B

B

icariside II
113558-15-9

icariside II

Conditions
ConditionsYield
With glycosyltransferase from Carthamus tinctorius (L.) (Honghua) recombinant; UDP; Cleland's reagent In aq. buffer at 30℃; for 12h; pH=7.4; Enzymatic reaction; regiospecific reaction;A 26 %Chromat.
B 24 %Chromat.
icariin
489-32-7

icariin

C27H30O11

C27H30O11

Conditions
ConditionsYield
With cell suspension cultures of Glycyrrhiza uralensis In N,N-dimethyl-formamide for 168h; Microbiological reaction; regioselective reaction;
icariin
489-32-7

icariin

(((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4H-chromene-3-yl)oxy)methyl)phosphonic acid

(((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4H-chromene-3-yl)oxy)methyl)phosphonic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
3: caesium carbonate / acetone / Inert atmosphere; Reflux
4: 2,6-dimethylpyridine; trimethylsilyl bromide / dichloromethane / 20 °C / Inert atmosphere
View Scheme
icariin
489-32-7

icariin

(((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4H-chromen-3-yl)oxy)methyl)phosphonate disodium

(((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4H-chromen-3-yl)oxy)methyl)phosphonate disodium

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
3: caesium carbonate / acetone / Inert atmosphere; Reflux
4: 2,6-dimethylpyridine; trimethylsilyl bromide / dichloromethane / 20 °C / Inert atmosphere
5: sodium methylate / methanol / 0.5 h / 20 °C / Cooling with ice
View Scheme
icariin
489-32-7

icariin

6(((5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4Η-chromene-3,7-diyl)bis(oxy))bis(methyl))bis(phosphonic acid diethyl ester)

6(((5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4Η-chromene-3,7-diyl)bis(oxy))bis(methyl))bis(phosphonic acid diethyl ester)

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
3: caesium carbonate / acetone / Inert atmosphere; Reflux
View Scheme
icariin
489-32-7

icariin

(((5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)oxo-4Η-chromene-3,7-diyl)bis(oxy))bis(methylene))bisphosphonate sodium

(((5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)oxo-4Η-chromene-3,7-diyl)bis(oxy))bis(methylene))bisphosphonate sodium

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
3: caesium carbonate / acetone / Inert atmosphere; Reflux
4: 2,6-dimethylpyridine; trimethylsilyl bromide / dichloromethane / 20 °C / Cooling with ice; Inert atmosphere
5: sodium hydroxide / methanol / 0.5 h
View Scheme
icariin
489-32-7

icariin

(((5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4H-chromene-3,7-diyl)bis(oxy))bis(methylene))bisphosphonic acid

(((5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4H-chromene-3,7-diyl)bis(oxy))bis(methylene))bisphosphonic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
3: caesium carbonate / acetone / Inert atmosphere; Reflux
4: 2,6-dimethylpyridine; trimethylsilyl bromide / dichloromethane / 20 °C / Cooling with ice; Inert atmosphere
View Scheme
icariin
489-32-7

icariin

(2S)-2-((((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en1-yl)-4-oxo-4H-chromen-3-yl)oxy)(ethoxy)phosphoryl)amino)-3-methylbutanoate

(2S)-2-((((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en1-yl)-4-oxo-4H-chromen-3-yl)oxy)(ethoxy)phosphoryl)amino)-3-methylbutanoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
3: triethylamine; dmap / dichloromethane / 49 h / 0 - 20 °C
View Scheme
icariin
489-32-7

icariin

2-((((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3-yl)oxy)(ethoxy)phosphoryl)amino)acetic acid ethyl ester

2-((((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3-yl)oxy)(ethoxy)phosphoryl)amino)acetic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
3: triethylamine; dmap / dichloromethane / 49 h / 0 - 20 °C
View Scheme
icariin
489-32-7

icariin

(((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4H-chromen-3-yl)oxy)methyl)phosphonate diethyl ester

(((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4H-chromen-3-yl)oxy)methyl)phosphonate diethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
3: caesium carbonate / acetone / Inert atmosphere; Reflux
View Scheme
icariin
489-32-7

icariin

C55H69NO22

C55H69NO22

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / N,N-dimethyl-formamide / 0.17 h / Cooling with ice
1.2: 6 h / Cooling with ice
2.1: potassium carbonate; potassium iodide / acetone / 0.17 h
2.2: 20 °C
3.1: potassium carbonate; potassium iodide / acetone / 0.17 h / 20 °C
3.2: 0.5 h / 20 °C
View Scheme
icariin
489-32-7

icariin

C50H59BrO22

C50H59BrO22

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / N,N-dimethyl-formamide / 0.17 h / Cooling with ice
1.2: 6 h / Cooling with ice
2.1: potassium carbonate; potassium iodide / acetone / 0.17 h
2.2: 20 °C
View Scheme
malonic acid
141-82-2

malonic acid

icariin
489-32-7

icariin

8-prenylkaempferol-4'-methylether-3-O-rhamnoside-7-O-(6-O-malonyl)-β-D-glucopyranoside

8-prenylkaempferol-4'-methylether-3-O-rhamnoside-7-O-(6-O-malonyl)-β-D-glucopyranoside

Conditions
ConditionsYield
With DL-dithiothreitol; MatB from Arabidopsis thaliana; NbMaT1; ATP; magnesium chloride; Coenzyme A In aq. phosphate buffer at 30℃; for 12h; pH=7.5; Enzymatic reaction;

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields