
Tetrahedron Letters p. 2493 - 2496 (1990)
Update date:2022-07-29
Topics:
Alcaide
Plumet
Rodriguez-Lopez
Sanchez-Cantalejo
A simple strategy for the synthesis of various α-alkylidene-β-lactams 4 based upon the condensation between lithium enolates of 3-(N,N-dialkylamino)esters and imines followed by straightforward deamination of the resulting 3-aminoalkyl-β-lactams 3 is outlined. The synthesis of α-alkylidene-β-formyl-β-lactams is a particularly significant feature of this work.
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(2017)