Carboxyl-mediated Pictet-Spengler reaction. Direct synthesis of 1,2,3,4-tetrahydro β-carbolines from tryptamine-2-carboxylic acids

DOI: 10.1016/S0040-4039(00)97406-9

Source and publish data:

Tetrahedron Letters p. 3397 - 3400 (1990)

Update date:2022-07-30

Topics:

Authors:

Narayanan, Krishnaswamy

Cook, James M.

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Article abstract of DOI:10.1016/S0040-4039(00)97406-9

The Pictet-Spengler condensation of various tryptamine-2-carboxylic acids 1 with carbonyl compounds in benzene/dioxane/trifiuoroacetic acid (Table) with simultaneous loss of carbon dioxide, afforded directly the corresponding 1,2,3,4-tetrahydro β-carbolin

Full text of DOI:10.1016/S0040-4039(00)97406-9

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