Tandem Michael reactions for the construction of pyrrolidine and piperidine ring systems

Article abstract of DOI:10.1016/S0040-4039(00)89020-6

A convergent one-pot construction of disubstituted pyrrolidine and piperidine frameworks has been accomplished through a simple protocol involving intermolecular conjugate addition of a nitrogen nucleophile to an electrophilic olefin followed by intramolecular trapping of the generated enolate by a built-in α,β-unsaturated acceptor.