Reaction of 3-amino-2H-azirines with 2-amino-4,6-dinitrophenol (picramic acid): Synthesis of quinazoline- and 1,3-benzoxazole derivatives

Article abstract of DOI:10.1002/hlca.19900730423

The reaction of 3-(dimethylamino)-2H-azirines 1a-c and 2-amino-4,6-dinitrophenol (picramic acid, 2) in MeCN at 0° to room temperature leads to a mixture of the corresponding 1,2,3,4-tetrahydroquinazoline-2-one 5, 3-(dimethylamino)-1,2-dihydroquinazoline 6