Synthesis and positive inotropic activity of novel pyrimido-[5,4-b][1,4]oxazin-7(8H)-ones

Article abstract of DOI:10.1016/0223-5234(90)90117-L

Seventy-five compounds I were synthesized and tested for positive inotropic activity. Some derivatives (22, 24, 54) showed an activity comparable to that of amrinone. Compound 24 was selected for preclinical study. According to the biochemical and pharmacological data its activity may involve a novel mechanism(s).