Synthesis and positive inotropic activity of novel pyrimido-[5,4-b][1,4]oxazin-7(8H)-ones

DOI: 10.1016/0223-5234(90)90117-L

Source and publish data:

European Journal of Medicinal Chemistry p. 333 - 341 (1990)

Update date:2022-07-29

Topics: Synthesis Chemical reactions Heterocyclic Positive inotropic activity

Authors:

Kasztreiner

Rabloczky

Makk Makk

Matyus Matyus

Diesler Diesler

Tegdes Tegdes

Kosary Kosary

Czako Czako

Gyurki Gyurki

Cseh Cseh

Kurthy Kurthy

Jaszlits

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Article abstract of DOI:10.1016/0223-5234(90)90117-L

Seventy-five compounds I were synthesized and tested for positive inotropic activity. Some derivatives (22, 24, 54) showed an activity comparable to that of amrinone. Compound 24 was selected for preclinical study. According to the biochemical and pharmacological data its activity may involve a novel mechanism(s).

Full text of DOI:10.1016/0223-5234(90)90117-L

Products guided by the article

Product name:2-phenyl-4-tosyloxy-6,7-dihydropyrimido<5,4-b><1,4>oxazin-7(8H)-one

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