Potential Antimitotic Agents. Synthesis of Some Ethyl Benzopyrazin-7-ylcarbamates, Ethyl Pyridopyrazin-7-ylcarbamates, and Ethyl Pyrido-as-triazin-7-ylcarbamates

Article abstract of DOI:10.1021/jm00173a021

Ring analogues and derivatives of the 1,2-dihydropyrido<3,4-b>pyrazin-7-ylcarbamates (e.g., 29), antimitotic agents with antitumor activity, were prepared in the search for compounds with greater selectivity.Methods were developed for the conversion of su