(R)- and (S)-4-Methylaminomethyl-2,3,4,9-tetrahydrothiopyranoindole: Synthesis, Absolute Configuration, Conformation, and Analgesic Activity

DOI: 10.1039/P19900000827

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 827 - 837 (1990)

Update date:2022-07-29

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Authors:

Ishizuka, Natsuki

Shiro, Motoo

Makisumi, Yasuo

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Article abstract of DOI:10.1039/P19900000827

(R)- and (S)-4-Methylaminomethyl-2,3,4,9-tetrahydrothiopyrano<2,3-b>indole (2) have been synthesized and their conformation studied. (RS)-(2) has been found to be a potent non-narcotic analgesic agent.The crucial step was regio- and stereo-specific cycliz

Full text of DOI:10.1039/P19900000827

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