(R)- and (S)-4-Methylaminomethyl-2,3,4,9-tetrahydrothiopyranoindole: Synthesis, Absolute Configuration, Conformation, and Analgesic Activity

DOI: 10.1039/P19900000827

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 827 - 837 (1990)

Update date:2022-07-29

Topics:

Authors:

Ishizuka, Natsuki

Shiro, Motoo

Makisumi, Yasuo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/P19900000827

(R)- and (S)-4-Methylaminomethyl-2,3,4,9-tetrahydrothiopyrano<2,3-b>indole (2) have been synthesized and their conformation studied. (RS)-(2) has been found to be a potent non-narcotic analgesic agent.The crucial step was regio- and stereo-specific cycliz

Full text of DOI:10.1039/P19900000827

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:4-methylaminomethyl-2,3,4,9-tetrahydrothiopyrano<2,3-b>indole hydrochloride

Cas No:130222-43-4

R&D Labs maybe for 130222-43-4

Xi'an Herbland Tech Inc.

Contact:+86-29-88710656

Address:South Tai bai Road, High Tech Development Zone, Xi'an China
SPRING CHEMICAL INDUSTRY CO.,LTD

Contact:86-187-66672125

Address:linchi industry park.zouping
Wuxi Olite Chemical Co., Ltd.

Contact:86-510-82853889

Address:Rm.3732, No.18-2,Yonghe Rd.,Wuxi,Jiangsu,214023,China
Beijing Mashi Fine Chemical Co.,Ltd.

Contact:+86-10-61271592

Address:Room 506, Section B, Kaichi Mansion, Industrial Development
SuZhou Hua-Emy Chemical Import and Export Co., LTD.

Contact:+86-512-88804994; +86-512-88804550;

Address:710, Building B, International Trade Center, 12 Huanghelu, Changshu, Jiangsu,China

Relevant to this article

Pyrazole derivatives as potent inhibitors of c-Jun N-terminal kinase: Synthesis and SAR studies

Doi:10.1016/j.bmc.2014.08.028
(2014)
Sulfation of O-isopropylidenated lactose derivatives at the 2'-position induces an unusual ^3,0B-boat conformation of the D-galactosyl residue

Doi:10.1016/0008-6215(90)84234-L
(1990)
Preparation of novel 2,3,8-trisubstituted pyrido[3,4-b]pyrazines and pyrido[2,3-b]pyrazines

Doi:10.1055/s-0030-1259429
(2011)
Synthesis of (-)-viriditoxin: A 6,6′-binaphthopyran-2-one that targets the bacterial cell division protein FtsZ

Doi:10.1002/anie.201007298
(2011)
Synthesis of the anomeric ethyl 2-(4,6-di-O-benzyl-2,3-dideoxy-D-erythro-hex-2-enopyranosyl)acetates and their structural characterization

Doi:10.1016/0008-6215(90)80054-7
(1990)
Scope and limitations of oxidative decarboxylation of α-(acylamino) acids by peroxy acids: Conversion of a 2-azetidinone-4-carboxylic acid to a carbapenem

Doi:10.1055/s-1990-26983
(1990)

Article Doi