Journal of Organic Chemistry p. 2573 - 2576 (2004)
Update date:2022-08-05
Topics:
White, Jonathan M.
Tunoori, Ashok Rao
Turunen, Brandon J.
Georg, Gunda I.
The use of the Deoxo-Fluor reagent is a versatile method for acyl fluoride generation and subsequent one-flask amide coupling. It provides mild conditions and facile purification of the desired products in good to excellent yields. We have explored the utility of this reagent for the one-flask conversion of acids to amides and Weinreb amides and as a peptide-coupling reagent.
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