Synthesis of 3-Alkoxyalkanoic Esters from Acetals. A Novel Application of Reformatsky Reagents in Asymmetric Synthesis

Article abstract of DOI:10.1055/s-1990-26859

3-Alkoxyalkanoic esters are directly obtained in high yield from the reaction of acetals with Reformatsky reagents in the presence of titanium(IV)chloride or diethyl ether-boron trifluoride complex in dichloromethane.The reaction of ethyl 4-bromo-2-buteno