Bioorganic and Medicinal Chemistry Letters p. 2354 - 2358 (2011)
Update date:2022-09-26
Topics:
Trotter, B. Wesley
Nanda, Kausik K.
Burgey, Christopher S.
Potteiger, Craig M.
Deng, James Z.
Green, Ahren I.
Hartnett, John C.
Kett, Nathan R.
Wu, Zhicai
Henze, Darrell A.
Penna, Kimberly Della
Desai, Reshma
Leitl, Michael D.
Lemaire, Wei
White, Rebecca B.
Yeh, Suzie
Urban, Mark O.
Kane, Stefanie A.
Hartman, George D.
Bilodeau, Mark T.
A new series of imidazopyridine CB2 agonists is described. Structural optimization improved CB2/CB1 selectivity in this series and conferred physical properties that facilitated high in vivo exposure, both centrally and peripherally. Administration of a h
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