CYCLOCONDENSATION OF α-OXOKETENE DITHIOACETALS WITH β-LITHIOAMINO-β-SUBSTITUTED ACRYLONITRILES: SYNTHESIS OF 2,6-SUBSTITUTED AND 5,6-ANNELATED 3-CYANO-4-(METHYLTHIO)PYRIDINES

DOI: 10.1016/S0040-4020(01)81540-4

Source and publish data:

Tetrahedron p. 3703 - 3714 (1990)

Update date:2022-07-31

Topics:

Authors:

Gupta, Arun K.

Ila, Hiriyakkanavar

Junjappa, Hiriyakkanavar

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Article abstract of DOI:10.1016/S0040-4020(01)81540-4

The lithiated β-amino-β-substituted acrylonitriles 4a-d generated in situ by reaction of lithioacetonitrile with either acetonitrile or substituted nitriles undergo cyclocondensation with α-oxoketenedithioacetate through 1,4-addition to afford 2,6-substit

Full text of DOI:10.1016/S0040-4020(01)81540-4

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