Bioorganic and Medicinal Chemistry Letters p. 2335 - 2340 (2011)
Update date:2022-08-05
Topics:
Xu, Rui
Banka, Anna
Blake, James F.
Mitchell, Ian S.
Wallace, Eli M.
Bencsik, Josef R.
Kallan, Nicholas C.
Spencer, Keith L.
Gloor, Susan L.
Martinson, Matthew
Risom, Tyler
Gross, Stefan D.
Morales, Tony H.
Wu, Wen-I
Vigers, Guy P.A.
Brandhuber, Barbara J.
Skelton, Nicholas J.
We describe the design and synthesis of novel bicyclic spiro sulfonamides as potent Akt inhibitors. Through structure-based rational design, we have successfully improved PKA selectivity of previously disclosed spirochromanes. Representative compounds sho
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