A synthesis of (-)-tetrahydrolipstatin in which the relative stereochemistry is controlled by a phenyldimethylsilyl group

Article abstract of DOI:10.1016/S0040-4039(00)94466-6

The alkylation ofa β-silylenolate and the hydroboration of an allylsilane successively control the relative stereochemistry of the three stereogenic centres on the carbon backbone in a synthesis of the esterase inhibitor tetrahydrolipstatin (21).