7664-38-2

Usage

Uses

Used in Fertilizer Production:
Orthophosphoric acid is used as a key ingredient in the production of fertilizers for enhancing plant growth and development. It provides essential phosphorus, a vital nutrient for plants, which promotes root growth, flowering, and fruiting.
Used in Detergent Manufacturing:
Orthophosphoric acid is used as a builder in detergent formulations to enhance cleaning efficiency. It helps to soften water, remove mineral deposits, and improve the overall performance of detergents.
Used in Food Industry:
Orthophosphoric acid is used as a flavor enhancer and acidulant in the food industry. It imparts a tangy taste to various food products and helps to maintain their freshness and quality. Additionally, it serves as a pH regulator and preservative, ensuring the stability and shelf life of food products.
Used in Pharmaceutical Industry:
Orthophosphoric acid is used in the production of phosphate salts, which are essential in many pharmaceutical formulations. These salts play a crucial role in various medical applications, such as bone health, enzyme activation, and energy metabolism.
Used in Dental Applications:
Orthophosphoric acid is used as an etchant in dental procedures to clean and roughen tooth surfaces before bonding procedures. It helps to create a strong bond between the tooth and dental materials, ensuring the longevity and effectiveness of dental treatments.
However, it is important to note that orthophosphoric acid is a strong acid and can cause burns and irritation upon contact with the skin and eyes. Therefore, proper handling and safety precautions are necessary when working with this chemical.

InChI:InChI=1/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)

Synthetic route

orthophosphoric acid (7664-38-2) + calcium carbonate → hydroxyapatite

Conditions	Yield
In water acid soln. neutralization with Ca-compd. soln. (phenolphthalein) at roomtemp. or at 80-90°C, suspn. stirring for 0.5 h; ppt. washing (water), drying at 80°C overnight or. ppt. ageing for 1 h, 5, 10, 15 or 30 d, sample part calcination at 900°C;

orthophosphoric acid (7664-38-2) + calcium hydroxide → hydroxyapatite

Conditions	Yield
In water acid soln. neutralization with Ca-compd. soln. (phenolphthalein) at roomtemp. or at 80-90°C, suspn. stirring for 0.5 h; ppt. washing (water), drying at 80°C overnight or. ppt. ageing for 1 h, 5, 10, 15 or 30 d, sample part calcination at 900°C;

Upstream product

• 7647-01-0 hydrogenchloride 
• 7726-95-6 bromine 
• 5337-17-7 4-aminophenylphosphonic acid 
• 66-72-8 pyridoxal 
• 7705-08-0 iron(III) chloride 
• 7758-99-8 copper(II) sulfate 
• 144-62-7 oxalic acid 
• 132-06-9 inosine 5'-triphosphate 
• 114252-96-9 O^5'-(hydroxy-sulfooxy-phosphoryl)-O^2'_,O3'-disulfo-adenosine 
• 7732-18-5 water 
• 878-17-1 4-methylphenyl phosphorodichloridate 
• 762-04-9 phosphonic acid diethyl ester 
• 2465-65-8 O,O'-diethyl thiophosphoric acid 
• 770-12-7 O-phenyl phosphorodichloridate 

Downstream Products

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• 88-15-3 2-Acetylthiophene 
• 19055-93-7 1,3-diazepan-2-one 
• 1689-79-8 3-tert-butylthiophene 
• 1689-78-7 2-tert-butylthiophene 
• 1689-77-6 2,5-di-tert-butylthiophene 
• 607-71-6 4-methyl-2H-chromen-2-one 
• 1839-72-1 2-phenylbenzofuran 
• 39565-07-6 7-amino-2,4-dimethyl-1,8-naphthyridine 
• 942-01-8 1,2,3,4-tetrahydrocarbazole 
• 92-83-1 xanthene 
• 90-47-1 xanth-9-one 
• 1015-89-0 6(5H)-phenanthridinone 
• 7076-11-1 5,6,7,8-tetrahydro-9H-pyrido<2,3-b>indole 

Relevant academic research and scientific papers

Oxidative hydroxylation of phosphine in aqueous alcohol solutions of p-benzoquinone

The oxidation of phosphine in aqueous alcohol solution of benzoquinone in the presence of iodide ions is studied. Kinetic measurements, redox potentiometry, and gas chromatography are used to determine the kinetic regularities of the oxidative hydroxylati

Thermal transformations of Co(H2PO4)2·2H2O

Thermal transformations of Co(H2PO4)2·2H2O in air, vacuum, water-vapor atmosphere were studied by the methods of DTA, XRD, paper chromatographic analyses and gravimetry. It was established that the removal of th

A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1

The development of deoxynucleoside triphosphate (dNTP)-based drugs requires a quantitative understanding of any inhibition, activation, or hydrolysis by off-target cellular enzymes. SAMHD1 is a regulatory dNTP-triphosphohydrolase that inhibits HIV-1 replication in human myeloid cells. We describe here an enzyme-coupled assay for quantifying the activation, inhibition, and hydrolysis of dNTPs, nucleotide analogues, and nucleotide analogue inhibitors by triphosphohydrolase enzymes. The assay facilitates mechanistic studies of triphosphohydrolase enzymes and the quantification of off-target effects of nucleotide-based antiviral and chemotherapeutic agents.

Reactivity of free and CoIII-co-ordinated phosphite; mechanisms of bromine oxidation and H/D exchange

The complexes t- and p-[Co(tren)(NH3){OP(H)(O)2}]ClO4 (1·ClO4 and 2-ClO4, respectively) and syn(OP(H)(O)2), anti(OH2)-[Co(cyclen)(OH2){OP(H)(O)2}]ClO 4

H3PO3 electrochemical behaviour on a bulk Pt electrode: adsorption and oxidation kinetics

Polybenzimidazole-type polymer doped with H3PO4 is commonly used as the proton-conductive phase in high-temperature proton-exchange membrane fuel cells. However, H3PO4 is not stable during fuel cell operation and undergoes reduction by hydrogen on a Pt surface to phosphorus compounds in a lower oxidation state, such as H3PO3. In this work the kinetics of H3PO3 oxidation on Pt electrode was studied, including an investigation of H4P2O6 as a possible oxidation intermediate. H3PO3 adsorption in hydrogen underpotential deposition region was described by a triple Langmuir isotherm corresponding to adsorption on specific Pt crystalline planes. Co-adsorption of hydrogen as well as SO42?, HSO4? ions decreased the total amount of adsorbed H3PO3. The determined apparent charge transfer coefficients of H3PO3 anodic oxidation on a metallic Pt surface were found to be concentration and temperature-dependent, indicating that the nature of the anodic process is complex. From chronopotentiometric measurements of H3PO3 and H4P2O6 oxidation on a preoxidised Pt surface it was concluded that, while H3PO3 is oxidised by means of a chemical reaction with PtOx, H4P2O6 undegoes anodic oxidation on the PtOx surface. According to voltammetry and bulk electrolysis experiments H4P2O6 is not formed as an intermediate product during electrochemical oxidation of H3PO3 on a metallic Pt surface.

PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond

The sequential activities of PhnY, an α-ketoglutarate/Fe(II)- dependent dioxygenase, and PhnZ, a Fe(II)-dependent enzyme of the histidine-aspartate motif hydrolase family, cleave the carbon-phosphorus bond of the organophosphonate natural product 2-aminoethylphosphonic acid. PhnY adds a hydroxyl group to the α-carbon, yielding 2-amino-1-hydroxyethylphosphonic acid, which is oxidatively converted by PhnZ to inorganic phosphate and glycine. The PhnZ reaction represents a new enzyme mechanism for metabolic cleavage of a carbon-phosphorus bond.

Synthesis, Stability, and Kinetics of Hydrogen Sulfide Release of Dithiophosphates

The development of chemicals to slowly release hydrogen sulfide would aid the survival of plants under environmental stressors as well as increase harvest yields. We report a series of dialkyldithiophosphates and disulfidedithiophosphates that slowly degrade to release hydrogen sulfide in the presence of water. Kinetics of the degradation of these chemicals were obtained at 85 °C and room temperature, and it was shown that the identity of the alkyl or sulfide group had a large impact on the rate of hydrolysis, and the rate constant varied by more than 104×. For example, using tert-butanol as the nucleophile yielded a dithiophosphate (8) that hydrolyzed 13,750× faster than the dithiophosphate synthesized from n-butanol (1), indicating that the rate of hydrolysis is structure-dependent. The rates of hydrolysis at 85 °C varied from a low value of 6.9 × 10-4 h-1 to a high value of 14.1 h-1. Hydrogen sulfide release in water was also quantified using a hydrogen sulfide-sensitive electrode. Corn was grown on an industrial scale and dosed with dibutyldithiophosphate to show that these dithiophosphates have potential applications in agriculture. At a loading of 2 kg per acre, a 6.4% increase in the harvest yield of corn was observed.

Efficient hydrolytic cleavage of phosphodiester with a lanthanide-based metal-organic framework

Hydrolysis of phosphate diesters has attracted substantial research efforts, not only in bio-organic chemistry, but also in inorganic chemistry. Herein, a lanthanide-based metal-organic framework was synthesized by incorporating a tetraphenylethylene moiety as the four-point connected node, Ce-TCPE (noted as 1). The structural analyses indicate that 1 exhibits 3D framework connected by the sharing carboxylate groups with two kinds of 1D rhombic channels when viewed along the c direction. Hydrolytic cleavage catalysis have been performed and showed that 1 could act as efficient heterogeneous catalyst for the hydrolytic cleavage of the phosphodiester BNPP (bis(p-nitrophenyl)phosphate) with the high activity and hydrolytic stability in a pseudo-first-order rate. DFT studies has also gain an insight analysis to elucidate the cleavage process.

Hydrolysis of element (White) phosphorus under the action of heterometallic cubane-type cluster {mo3pds4}

Reaction of heterometallic cubane-type cluster complexes—[Mo3{Pd(dba)}S4Cl3(dbbpy)3]PF6, [Mo3{Pd(tu)}S4Cl3(dbbpy)3]Cl and [Mo3{Pd(dba)}S4/s

Synthesis, crystal structure, IR, Raman spectroscopy, and DFT computation of metacarboxyphenyl ammonium dihydrogenomonophosphate (C7H4NH3OOH) H2PO4(m-C AMP)

The metacarboxyphenyl ammonium dihydrogenomonophosphate (C7H4NH3OOH) H2PO4 was synthesized and studied by a combination of single-crystal X-ray diffraction analysis, infrared, Raman vibrational spectroscopy, and density functional computation (DFT) calculation. This compound crystallizes in the monoclinic system, with the central space group P21/c. Its unit-cell dimensions are a = 12.9361 (7) (?), b = 11.7735 (6) (?), c = 6.5764 (4) (?), β = 102.668° (2), and V = 977.22 (9) ?3.The structure determined gives a clear description of the hydrogen bonds connecting the hydrogen phosphate H2PO4– with the organic matrix. The atomic arrangement of this compound is built up by symmetric (H4P2O8)2– dimers anions formed by two (H2PO4)– via hydrogen bonding O1—H…O3. Each (H2PO4)– aggregates with cation through hydrogen bond interactions of O–H…O(P) and N–H…O(P) types. The bands observed in the infrared and Raman spectra of (C7H4NH3OOH) H2PO4 are assigned based on the results obtained in the literature and based on the computational group analyses performed in the factor group C2h. Besides, the optimal molecular geometry, harmonic vibration frequencies, infrared intensities, and Raman scattering activities were calculated using the DFT approach performed with the Gaussian 09 program using the hybrid function B3LYP combining the three Becke parameters and the Lee-Yang-Parr exchange-correlation function using the 6-311 + G(d,p) base set. The highest occupied molecular orbital–lowest unoccupied molecular orbital properties and geometries of this compound were determined and discussed. The results of the calculated structural parameters are generally in agreement with the experimental investigations. The computational infrared and Raman spectra of the reference compound have been constructed.