Synthesis of some 1-(dihydroxypropyl)pyrazolo-pyrimidines and in vivo evaluation of their antileishmanial and antitrypanosomal activity

Article abstract of DOI:10.1016/0223-5234(90)90005-N

A number of 1-(2,3-dihydroxypropyl)- and 1-<2-(1,3-dihydroxypropyl)>pyrazolo<3,4-d>pyrimidines were synthesized.Some of these compounds were evaluated for their activity against Leishmania infantum and Trypanosoma brucei brucei in mice.The highest degree of antileishmanial activity was displayed by the 4-amino-1-(RS)-(2,3-dihydroxypropylpyrazolo<3,4-d>pyrimidine 11a, which yielded a 87percent and 96percent parasite inhibition in a standard 5-day test and in a long-term (14 days) treatment, respectively, though full cures of animals were not achieved.On the contrary, thisderivative did not significantly prolong the survival of T b brucei infected mice.