Chemoenzymatic synthesis with lipase catalyzed resolution and evaluation of antitumor activity of (R/S)-2-[2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl]-1H- pyrrolo[3,4-b]quinolin-3(2H)-one

DOI: 10.1016/j.ejmech.2011.02.069

Source and publish data:

European Journal of Medicinal Chemistry p. 2152 - 2156 (2011)

Update date:2022-08-04

Topics: Lipase Chemoenzymatic synthesis Resolution Antitumor Activity

Authors:

Nagarapu, Lingaiah

Gaikwad, Hanmant K.

Bantu, Rajashaker

Manikonda, Sheeba Rani

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Article abstract of DOI:10.1016/j.ejmech.2011.02.069

Synthesis, characterization, resolution and evaluation of novel (R/S)-2-[2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl]-1H-pyrrolo[3,4-b] quinolin-3(2H)-one derivatives are described. Enantiomerically pure compounds were isolated in good to excellent yield w

Full text of DOI:10.1016/j.ejmech.2011.02.069

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