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| CAS No.: | 75-75-2 |
|---|---|
| Name: | Methanesulfonic acid |
| Article Data: | 152 |
| Cas Database | |
| Molecular Structure: | |
|
|
|
| Formula: | CH4O3S |
| Molecular Weight: | 96.107 |
| Synonyms: | Methanesulfonic Acid;Methanesulfonic acid; |
| EINECS: | 200-898-6 |
| Density: | 1.511 g/cm3 |
| Melting Point: | 19 °C |
| Boiling Point: | 167 °C (10 torr) |
| Flash Point: | >230 °F |
| Solubility: | Miscible with water. Slightly miscible with benzene and toluene. Immiscible with paraffins. |
| Appearance: | colourless or light yellow liquid |
| Hazard Symbols: |
 C
|
| Risk Codes: | 34-22 |
| Safety: | 26-36-45-1/2-36/37/39 |
| Transport Information: | UN 3265 8/PG 2 |
| PSA: | 62.75000 |
| LogP: | 0.58480 |
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- 67-56-1
methanol
- 82220-45-9
methanesulfonic phosphoric anhydride, diisopropyl ester
A
- 75-75-2
methanesulfonic acid
B
- 26955-63-5, 129149-78-6
diisopropyl methyl phosphate
| Conditions | Yield |
|---|---|
| for 1h; Ambient temperature; | A 100% B 98% |
| Conditions | Yield |
|---|---|
| With dihydrogen peroxide; methanesulfonic acid In water at 40 - 110℃; for 10h; | 100% |
| With dihydrogen peroxide In water at 35 - 45℃; for 10h; | 100% |
| With nitric acid at 80℃; for 8h; Concentration; Temperature; | 93.75% |
| With Mg(2+)*O4V(3-)*C19H42N(1+); dihydrogen peroxide In acetonitrile at 20 - 40℃; for 25h; Reagent/catalyst; Temperature; | 63.9% |
- 67-56-1
methanol
- 4972-37-6
methanesulfonic phosphoric anhydride, diethyl ester
A
- 75-75-2
methanesulfonic acid
B
- 867-17-4
diethyl methyl phosphate
| Conditions | Yield |
|---|---|
| for 1h; Ambient temperature; | A 91% B 99% |
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water at 40℃; for 3h; Temperature; | 98.4% |
| Conditions | Yield |
|---|---|
| With sulfuric acid; dihydrogen peroxide at 10 - 50℃; under 60006 - 90009 Torr; for 10h; Inert atmosphere; | 97% |
| Product distribution / selectivity; |
A
- 75-75-2
methanesulfonic acid
B
- 1033736-87-6
C16H10O3S
| Conditions | Yield |
|---|---|
| In chloroform-d1 for 0.216667h; Photolysis; Inert atmosphere; | A 96% B n/a |
- 34557-54-5
methane
- 75-75-2
methanesulfonic acid
| Conditions | Yield |
|---|---|
| With sulfuric acid; alumina; sulfur trioxide; dihydrogen peroxide In water at 50℃; under 21002.1 - 75007.5 Torr; for 3.5h; Reagent/catalyst; Autoclave; | 95% |
| With Methyl methanesulfonate; sulfur trioxide In fluorosulphonic acid at 50℃; under 75007.5 Torr; for 10h; | 93% |
| With sulfur trioxide at 50℃; under 75007.5 Torr; Autoclave; | 91% |
| Conditions | Yield |
|---|---|
| With nitric acid at 80℃; for 6h; Temperature; | 93.8% |
| With Mg(2+)*O4V(3-)*C19H42N(1+); water; oxygen In acetonitrile at 90℃; under 30003 Torr; for 24h; Reagent/catalyst; Pressure; Temperature; Autoclave; | 92% |
| With oxygen In methanol at 30 - 40℃; for 14h; Irradiation; | 65% |
- 1404369-05-6
1-(methanesulfonoyloxy)-2(1H)-quinolone
A
- 75-75-2
methanesulfonic acid
B
- 59-31-4, 70254-42-1
2-quinolone
| Conditions | Yield |
|---|---|
| In methanol; water Quantum yield; UV-irradiation; Photolysis; | A 90% B n/a |
| Conditions | Yield |
|---|---|
| With sulfuric acid; sulfur trioxide; dihydrogen peroxide at 50℃; under 75007.5 Torr; Large scale; | A 82% B n/a |
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Specification
Methanesulfonic acid is a colorless liquid with the chemical formula CH3SO3H. It is the simplest of the alkylsulfonic acids. Salts and esters of methanesulfonic acid are known as mesylates. It is also called Methanesulphonic acid, methanesulphonic-acid-, Sulfomethane, CCRIS 2783, HSDB 5004. Methanesulfonic acid is used as an acid catalyst in organic reactions because it is non-volatile, strong acid that is soluble in organic solvents.Methanesulfonic acid toxic is people .It shoule be Keeped locked up and out of the reach of children.when you use it, you should wear suitable protective clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).
Physical properties about Methanesulfonic acid are:
(1)ACD/LogP: -2.087; (2)ACD/LogD (pH 5.5): -5.39; (3)ACD/LogD (pH 7.4): -5.58; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00 ; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 3 ; (9)#H bond donors: 1; (10)Index of Refraction: 1.448; (11)Molar Refractivity: 17.019 cm3; (12)Molar Volume: 63.581 cm3; (13)Polarizability: 6.747 10-24cm3; (14)Surface Tension: 53.3790016174316 dyne/cm; (15)Density: 1.512 g/cm3
Preparation of Methanesulfonic acid:
A process for the preparation of methanesulfonic acid comprising reacting sulfite ions within an aqueous system with dimethyl sulfate at an elevated temperature and, subsequently, adding a strong acid, wherein the molar ratio of sulfite ions to dimethyl sulfate is 1.5 to 2.5:1, and the reaction is maintained at said elevated temperature for at least 2 h.
Uses of Methanesulfonic acid:
Methanesulfonic acid may be considered an intermediate compound between sulfuric acid (H2SO4), and methylsulfonylmethane ((CH3)2SO2), effectively replacing an -OH group with a -CH3 group at each step. This pattern can extend no further in either direction without breaking down the -SO2 group. Methanesulfonic acid can be used in the generation of BH3. By reacting methanesulfonic acid with NaBH4 in an aprotic solvent such as THF or DMS, the complex of BH3 and the solvent is formed.
You can still convert the following datas into molecular structure:
(1)InChI=1S/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4);
(2)InChIKey=AFVFQIVMOAPDHO-UHFFFAOYSA-N;
(3)SmilesS(=O)(=O)(C)O;
The toxicity data of Methanesulfonic acid is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | skin | > 2gm/kg (2000mg/kg) | Kodak Company Reports. Vol. 21MAY1971, | |
| quail | LD50 | oral | 1gm/kg (1000mg/kg) | Journal of Reproduction and Fertility. Vol. 48, Pg. 371, 1976. | |
| rat | LC | inhalation | > 330ppm/6H (330ppm) | Kodak Company Reports. Vol. 21MAY1971, | |
| rat | LD50 | oral | 200mg/kg (200mg/kg) | Kodak Company Reports. Vol. 21MAY1971, |
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