Specific Bradycardic Agents. 2. Heteroaromatic Modifications in the Side Chain of Specific Bradycardic Benzazepinones: Chemistry, Pharmacology, and Structure-Activity Relationships

DOI: 10.1021/jm00107a011

Source and publish data:

Journal of Medicinal Chemistry p. 942 - 947 (1991)

Update date:2022-08-02

Topics:

Authors:

Bomhard, Andreas

Reiffen, Manfred

Heider, Joachim

Psiorz, Manfred

Lillie, Christian

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00107a011

Compound 1 (UL-FS 49) has recently been described as the representative of a novel class of antiischemic compounds termed "specific bradycardic agents".In search of specific bradycardic agents with different pharmacokinetic profiles, heteroaromatic analog

Full text of DOI:10.1021/jm00107a011

Products guided by the article

Product name:3-(3-{[2-(5-Benzyloxy-1H-indol-3-yl)-ethyl]-methyl-amino}-propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one

Cas No:131079-65-7

R&D Labs maybe for 131079-65-7

Nanjing Ruizhi Industry & Technologh Co.，Ltd.

Contact:+86-25-86808110

Address:441-4-A5,NO.12 Longzang Avenue,Yuhuatai District,210039,Nanjing
Hangzhou yi lu biont technology Co., LTD

Contact:+86-571-88152630

Address:Hangzhoushi HuafengRoad Yicheng3Building1001room.
Aminodiscovery Co.,Ltd.

Contact:+86-535-8888888

Address:No.161 Haishi Rd.
Anhui Biochem United Pharmaceutical Co., Ltd.

Contact:0086 551 5167062 / 5228268

Address:No. 30 Hongfeng Road, Hi-Tech Development Zone, Hefei (230088), China
Shenzhen JYMed Technology Co.,Ltd.

website:http://www.jymedtech.com

Contact:+86-755-26612112

Address:1#8,9/F, Biomedicine innovation Industrial Park, No.14, Jinhui Road, Pingshan Sistrict, Shenzhen, China

Relevant to this article

The invention of radical reactions. Part XXVI. New thio- and seleno-hydroxamic acids; radical chemistry of their O-acyl derivatives

Doi:10.1016/S0040-4020(01)88250-8
(1992)
Neighbouring group effects promote substitution reactions over elimination and provide a stereocontrolled route to chloramphenicol

Doi:10.1016/0040-4020(96)00307-9
(1996)
Unexpected formation of (E)-4-alkene 1,3-diketones from the three-component reaction of lithium selenolates with 1-(1-alkynyl)cyclopropyl ketones and aldehydes

Doi:10.1021/jo2005439
(2011)
Synthesis of a tri- and a tetra-saccharide fragment of the capsular polysaccharide of type III group B Streptococcus.

Doi:10.1016/0008-6215(90)80134-O
(1990)
New multicomponent cyclization: Domino synthesis of pentasubstituted pyridines under solvent-free conditions

Doi:10.1039/c0ob01258k
(2011)
Studies of one-pot double couplings on dibromoquinolines

Doi:10.1016/j.tet.2011.04.052
(2011)

Article Doi