Journal of Organic Chemistry p. 751 - 762 (1991)
Update date:2022-09-26
Topics:
Mathre, David J.
Jones, Todd K.
Xavier, Lyndon C.
Blacklock, Thomas J.
Reamer, Robert A.
et al.
A practical two-step enantioselective synthesis of α,α-diaryl-2-pyrrolidinemethanols (1) from proline, based on the addition of aryl Grignard reagents to proline-N-carboxanhydride (3), is reported.An investigation into the chemistry of the corresponding B-alkyl- and B-aryloxazaborolidines (2) led to the development of a reliable procedure for their preparation.
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