A 3-D model for 5-HT(1A)-receptor agonists based on stereoselective methyl-substituted and conformationally restricted analogues of 8-hydroxy-2-(dipropylamino)tetralin

Article abstract of DOI:10.1021/jm00106a004

The enantiomers of cis- and trans-1,2,3,4,4a,5,10,10a-octahydro-9-hydroxy-1-propylbenzo[g] quinolines (10 and 11, respectively) and the enantiomers of trans-1,2,3,4,4a,5,6,10b-octahydro-10-hydroxy-4-propylbenzo[f] quinoline (12) have been synthesized and