Positional Effects of Sulfation in Hirudin and Hirudin PA Related Anticoagulant Peptides

DOI: 10.1021/jm00107a043

Source and publish data:

Journal of Medicinal Chemistry p. 1184 - 1187 (1991)

Update date:2022-08-04

Topics:

Authors:

Payne, Marguerite H.

Krstenansky, John L.

Yates, Mark T.

Mao, Simon J. T.

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Article abstract of DOI:10.1021/jm00107a043

C-Terminal fragment analogues of the leech protein hirudin or the related protein hirudin PA block thrombin's cleavage of fibrinogen.Three series of synthetic peptides were synthesized to study the effects of sulfation in hirudin-derived peptides.Potency

Full text of DOI:10.1021/jm00107a043

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