Nucleoside 3'-N,N-Dialkylphosphonamidates as Novel Nucleotide Units for the Solution-Phase Oligonucleotide Syntheis

Article abstract of DOI:10.1016/S0040-4020(01)86304-3

Nucleoside 3'-N,N-diisopropylphosphonamidate building blocks for oligonucleotide syntheis were prepared in high yields from appropriately protected nucleosides by use of chlorobis(N,N-diisopropylamino)phosphine as a phosphitylating reagent.The 5'-dimethox