Deprotection of carboxylic esters assisted by hydrogen bonding network in phenolic media. Its application to β-lactam antibiotic syntheses

DOI: 10.1016/S0040-4039(00)97140-5

Source and publish data:

Tetrahedron Letters p. 6661 - 6662 (1990)

Update date:2022-08-03

Topics:

Authors:

Tanaka, Hideo

Taniguchi, Masatoshi

Kameyama, Yutaka

Torii, Sigeru

Sasaoka, Michio

Shiroi, Takashi

Kikuchi, Ryo

Kawahara, Ichiro

Shimabayashi, Akihiro

Nagao, Sigemitsu

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Article abstract of DOI:10.1016/S0040-4039(00)97140-5

Deprotection of p-methoxybenzyl, diphenylmethyl, and tert-butyl ester groups, which is an essential step of β-lactam antibiotic synthesis, can be performed successfully by gentle heating in phenolic media.

Full text of DOI:10.1016/S0040-4039(00)97140-5

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