Synthesis of vinylphosphonates and its first exploration of bioactivity

Article abstract of DOI:10.2174/157017811796064467

Phosphonation of β-nitro-alkene with triethyl phosphite was achieved under microwave irradiation using CH₂Cl₂ as the solvent in the absence of catalyst with moderate to high yields (up to 90%). This method of formation of carbonphosphor bonds is simple, mild, convenient and effective. Synchronously, a number of vinylphosphonates derivatives were synthesized and evaluated biologically preliminary.