CHIRAL LIGANDS CONTAINING HETEROATOMS. 6. 1-(2-PYRIDYLMETHYL)PYRROLIDINE IN THE CHIRAL CATALYSIS OF ADDITION OF DIETHYLZINC TO BENZALDEHYDE

Article abstract of DOI:10.1016/S0957-4166(00)80448-6

The synthesis of a series of new optically active pyridine ligands from proline derivatives has been developed for the enantioselective addition of dialkyl zinc compounds to aldehydes.The results obtained indicate that the corrdination of a metal atom to the nitrogen of the pyridine ring is essential in determining the stereochemistry of the process.