Synthesis of nitrone analogues of RAR α selective retinoid Am 580

Article abstract of DOI:10.1080/00397919508011829

Synthesis of nitrone analogues of RAR α-selective retinoid Am 580 in which the amide linker is replaced with a nitrone moiety is described. The nitrone segment was constructed by oxidizing the corresponding amine using MCPBA or dimethyldioxirane. The resu

Full text of DOI:10.1080/00397919508011829

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Synthetic Communications: An
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Synthesis of Nitrone Analogues
of Rar α Selective Retinoid
AM580
Kuo-Long Yu a , Jacek Ostrowski b , Simon Chen b ,
Peter R. Reczek b , Muzammil M. Mansuri a & John E.
Starrett Jr a
a Bristol-Myers Squibb Company, Pharmaceutical
Research Institute, 5 Research Parkway, Wallingford,
Connecticut, 06492
b Westwood-Squibb Pharmaceuticals, 100 Forest
Avenue, Buffalo, New York, 14213
Version of record first published: 16 Feb 2007.
To cite this article: Kuo-Long Yu, Jacek Ostrowski, Simon Chen, Peter R. Reczek,
Muzammil M. Mansuri & John E. Starrett Jr (1995): Synthesis of Nitrone Analogues of
Rar α Selective Retinoid AM580, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 25:18, 2819-2827
To link to this article: http://dx.doi.org/10.1080/00397919508011829
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