Tetrahedron Letters p. 3319 - 3322 (1998)
Update date:2022-07-29
Topics: Isolate the product Purification Work-Up Add Acid Scavenger Prepare the Reaction Mixture Add Solvent Prepare a Solution of BOP Add BOP Solution Add Sodium Borohydride (NaBH4) Stir the Reaction
McGeary, Ross P.
Hydroxybenzotriazolyl esters, formed in situ from carboxylic acids and BOP reagent, react with sodium borohydride in THF to give alcohols in high yields. This method is convenient, rapid and chemoselective, with such functional groups as nitro, halide, nitrile, azido and ester being unaffected.
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