Bioorganic and Medicinal Chemistry Letters p. 5475 - 5479 (2011)
Update date:2022-08-05
Topics:
Subramanyam, Chakrapani
Duplantier, Allen J.
Dombroski, Mark A.
Chang, Shang-Poa
Gabel, Christopher A.
Whitney-Pickett, Carrie
Perregaux, David G.
Labasi, Jeff M.
Yoon, Kwansik
Shepard, Richard M.
Fisher, Michael
The discovery, of a series of 2-Cl-5-heteroaryl-benzamide antagonists of the P2X7 receptor via parallel medicinal chemistry is described. Initial analogs suffered from poor metabolic stability and low Vdss. Multi parametric optimizat
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