Studies directed towards the synthesis of immunosuppressive agent FK-506: Synthesis of the entire top-half

DOI: 10.1016/S0040-4039(00)79493-7

Source and publish data:

Tetrahedron Letters p. 547 - 550 (1991)

Update date:2022-08-03

Topics:

Authors:

Rama Rao

Chakraborty

Sankaranayanan

Purandare

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Article abstract of DOI:10.1016/S0040-4039(00)79493-7

An efficient approach has been developed to construct the entire TOP-HALF of FK-506 involving Grignard reaction of a C-29 bromide with a C-27 methylketo fragment.

Full text of DOI:10.1016/S0040-4039(00)79493-7

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