Synthesis of Aristotelia-Type Alkaloids. Part VI. Biomimetic Synthesis of (+)-Aristofruticosine

Article abstract of DOI:10.1002/hlca.19910740113

(S)-Perilla alcohol (5) was transformed into (S)-7-(phenylthio)-p-menth-1-en-8-amine (11) in five steps.Condensation of this building block with 1-(4-methoxyphenylsulfonyl)-1H-indole-3-acetaldehyde (12) led to the expected imine 15 which cyclized in 54 pe