6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.

DOI: 10.1021/jm9705115

Source and publish data:

Journal of medicinal chemistry p. 2047 - 2055 (1998)

Update date:2022-08-04

Topics:

Authors:

Pei Pei

Gupta Gupta

Badio Badio

Padgett Padgett

Daly Daly

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Article abstract of DOI:10.1021/jm9705115

A series of tropane derivatives, related in structure to baogongteng A (1), an alkaloid from a Chinese herb, were synthesized. 6beta-Acetoxynortropane (5) had weak affinity (Ki 22 microM) for central (M1) muscarinic receptors in a [3H]quinuclidinyl benzil

Full text of DOI:10.1021/jm9705115

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