Bioorganic and Medicinal Chemistry p. 5409 - 5419 (2011)
Update date:2022-09-26
Topics:
Kumar, Atul
Tripathi, Vishwa Deepak
Kumar, Promod
Gupta, Lalit Prakash
Akanksha
Trivedi, Ritu
Bid, Hemant
Nayak
Siddiqui, Jawed A.
Chakravarti, Bandana
Saxena, Ruchi
Dwivedi, Anila
Siddiquee
Siddiqui
Konwar, Rituraj
Chattopadhyay, Naibedya
A new series of 1,3-biarylsulfanyl derivatives (homodibenzyl core motif) have been designed and synthesized as new estrogen receptor ligands by chopping benzothiophene core of raloxifene to engender seco-raloxifene scaffold. All the synthesized compounds were screened for anti-proliferative, anti-osteoporotic, and anti-implantation activity. Compounds (35, 36) having basic amino anti-estrogenic side chain were exhibiting potential anti-proliferative activity in MCF-7, MDA-MB-231 and ishikawa cell lines. Some of the synthesized compounds having homodibenzyl motif (5, 8, 10) have shown moderate anti-osteoporotic activity.
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Doi:10.1080/10426500902967904
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