Catalytic asymmetric synthesis of (+)-anthecotulide using enyne and Meyer-Schuster rearrangements

Article abstract of DOI:10.1021/ol202425e

The bioactive sesquiterpene lactone (+)-anthecotulide (1) is synthesized for the first time, in a six-step sequence devoid of protecting groups. The key transformations are a novel Rh(I)-catalyzed asymmetric enyne rearrangement of a terminal alkynyl ester