
Tetrahedron p. 1603 - 1610 (1991)
Update date:2022-07-30
Topics:
Pautard-Cooper, Anne
Evans Jr., Slayton A.
Kenan Jr., William Rand
Stereo specific tosylate (-OTs) or azide (N3-) substitution at the C-4 stereocenter of a monosubstituted 1,3,2λ5-dioxaphospholane (the equivalent of the C-2 stereocenter in an unsymmetrical 1,2-diol) is readily achieved by treatment with either P-toluenesulfonic acid (P-TsOH) in tetrahydrofuran solvent or P-TsOH/sodium azide in acetonitrile solvent, respectively.
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Doi:10.1039/c1dt10661a
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(1991)