Asymmetric construction of trifluoromethylated pyrrolidines via Cu(i)-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with 4,4,4-trifluorocrotonates

DOI: 10.1039/c1cc14295j

Source and publish data:

Chemical Communications p. 11110 - 11112 (2011)

Update date:2022-08-04

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Authors:

Li, Qing-Hua

Tong, Min-Chao

Li, Jun Li, Jun

Tao, Hai-Yan

Wang, Chun-Jiang

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Article abstract of DOI:10.1039/c1cc14295j

Trifluoromethylated pyrrolidines have been synthesized via catalytic asymmetric 1,3-dipolar cycloaddition with excellent stereoselectivity for the first time. Epimerization of the endo-pyrrolidines obtained from cis-4,4,4-trifluorocrotonate into the exo-p

Full text of DOI:10.1039/c1cc14295j

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