Electrophilic γ-Lactone κ-Opioid Receptor Probes. Analogues of 2'-Hydroxy-2-tetrahydrofurfuryl-5,9-dimethyl-6,7-benzomorphan Diastereomers

Article abstract of DOI:10.1021/jm00112a019

Benzomorphans with an electrophilic group in the nitrogen substituent were prepared as potentially irreversible ligands for the κ-opioid receptor.These were synthesized from products of the reaction of normetazocine with the enantiomers of 5-(iodomethyl)-