Development, Synthesis, and Biological Evaluation of (-)-trans-(2S,5S)-2--4-n-propoxy-5-(3-hydroxypropoxy)-phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a Potent Orally Active Platelet-Activating Factor (PAF) Antagonist and

DOI: 10.1021/jm00097a005

Source and publish data:

Journal of Medicinal Chemistry p. 3474 - 3482 (1992)

Update date:2022-08-02

Topics:

Authors:

Girotra, N. N.

Biftu, T.

Ponpipom, M. M.

Acton, J. J.

Alberts, A. W.

et al. et al.

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Article abstract of DOI:10.1021/jm00097a005

(-)-trans-(2S,5S)-2-<3-<(2-Oxopropyl)sulfonyl>-4-n-propoxy-5-(3-hydroxypropoxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (10) is one of the most potent platelet-activating factor (PAF) antagonists in vitro and in vivo developed to date.This diaryl

Full text of DOI:10.1021/jm00097a005

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