Synthesis and alkylation of spiro-2-oxazolines containing fused 3,4-dihydropyrazin-2(1H)-ones

Article abstract of DOI:10.3987/COM-11-12299

Spiro-2-oxazolines containing 3,4-dihydroquinoxalin-2(1H)-one, 3,4-dihydrobenzoquinoxalin-2(1H)-one, 1,2-dihydropyrido[2,3-b]pyrazin-3(4H)- one or 5,6-dihydropteridin-7(8H)-one moiety were prepared by heating of aromatic or heteroaromatic diamines with 2-benzoylamino-3-chloropropenoic acid in the presence of triethylamine. Treatment of spiro-2-oxazolines with MeI or EtBr using Bu₄NHSO₄ and K₂CO₃ introduced the methyl or ethyl group on the lactam nitrogen atom.

Full text of DOI:10.3987/COM-11-12299

HETEROCYCLES, Vol. 83, No. 10, 2011
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HETEROCYCLES, Vol. 83, No. 10, 2011, pp. 2353 - 2364. © 2011 The Japan Institute of Heterocyclic Chemistry
Received, 7th July, 2011, Accepted, 4th August, 2011, Published online, 11th August, 2011
DOI: 10.3987/COM-11-12299
SYNTHESIS
AND
ALKYLATION
OF
SPIRO-2-OXAZOLINES
CONTAINING FUSED 3,4-DIHYDROPYRAZIN-2(1H)-ONES
Irena Mušič and Bojan Verček*
Faculty of Chemistry and Chemical Technology, University of Ljubljana,
Aškerčeva 5, SI-1000 Ljubljana, Slovenia. E-mail: bojan.vercek@fkkt.uni-lj.si
Abstract – Spiro-2-oxazolines containing 3,4-dihydroquinoxalin-2(1H)-one,
3,4-dihydrobenzoquinoxalin-2(1H)-one, 1,2-dihydropyrido[2,3-b]pyrazin-3(4H)-
one or 5,6-dihydropteridin-7(8H)-one moiety were prepared by heating of
aromatic or heteroaromatic diamines with 2-benzoylamino-3-chloropropenoic
acid in the presence of triethylamine. Treatment of spiro-2-oxazolines with MeI or
EtBr using Bu4NHSO4 and K2CO3 introduced the methyl or ethyl group on the
lactam nitrogen atom.
2-Oxazolines (4,5-dihydro-1,3-oxazoles) which contain spiro linkage at the carbon atom C4 with another
heterocyclic system represent a less known group of organic compounds. Such spirooxazolines have been
occasionally reported as intermediates, side products or unexpected products in various reactions. For
example, 4,5-dihydro-1,3-oxazole-4-spiro-2’-thiiranes were described as intermediates in the synthesis of
thietanes.1 One spiro-2-oxazoline derivative containing penicillin system was identified as a by-product in
the preparation of fluoromethyl substituted penicillin derivative.2 Spiro-2-oxazolines with protected sugar
moiety were prepared in some glycosidation reactions.3 Compounds with spiro 2-oxazoline structural
motif were also reported in the synthesis of parasitic insecticides.4 Recently, several spiro-2-oxazolines
were formed with a combinatorial approach to a structurally diverse library of polycyclic lactams.5
During the investigations of the transformations of simple amino acid derivatives,6 we designed a general
method for the formation of spiro-2-oxazolines having 3,4-dihydroquinoxalin-2(1H)-one, 3,4-dihydro-
benzoquinoxalin-2(1H)-one, 1,2-dihydropyrido[2,3-b]pyrazin-3(4H)-one or 5,6-dihydropteridin-7(8H)-
one system.6b This paper deals with the spirocyclic products obtained in our investigations in more detail.
 Dedicated to Professor Miha Tišler on the occasion of his 85th birthday

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HETEROCYCLES, Vol. 83, No. 10, 2011
Treatment of aromatic and heteroaromatic diamines 1 with 2-benzoylamino-3-chloropropenoic acid (2)7
in the presence of triethylamine in ethanol resulted in the formation of spiro-2-oxazolines 3 in 1750%
yields.
Reactions
with
o-phenylenediamines
1af
produced
1’H,5H-spiro[oxazole-4,2’-
quinoxalin]-3’(4’H)-ones 3af. When naphthalene-2,3-diamine 1g was applied, 1H,5’H-spiro[benzo-
[g]quinoxaline-2,4’-oxazole]-3(4H)-one 3g was formed. The use of pyridine-2,3-diamine 1h gave
1’H,5H-spiro[oxazole-4,2’-pyrido[3,2-b]pyrazin]-3’(4’H)-one 3h, while reaction with pyrimidine-2,3-
diamine 1i yielded 5H,5’H-spiro[oxazole-4,6’-pteridin]-7’(8’H)-one 3i (Scheme 1).
H
NH2
NH2
N
O
ClCH=C(NHCOPh)CO2H (2)
Et3N, EtOH, 
N
H
O
N
1
3
Ph
Diamines 1:
Spiro products 3:
R1
R1
H
N
H
N
R2
R3
O
O
R2
NH2
NH2
NH2
NH2
N
H
O
N
H
O
R3
N
N
1g
Yield (%)
Ph
Ph
R1 R2
R3
R1
R3
Yield (%)
R2
3g 28
1a
1b
1c
1d
1e
1f
H
H
H
H
H
H
H
Cl
N
NH2
NH2
NO2
H
H
H
NO2
Cl
N
NH2
NH2
H
N
H
N
3a
3b
3c
3c'
3d
3d'
3e
3e'
3f
23
17
H
NO2
H
H
H
H
H
H
H
H
H
NO2
H
H
Cl
COPh
H
Cl
H
H
H
NO2
Cl
H
H
COPh
Cl
N
O
N
O
N
46 (mixture of 3c
and 3c')
20 (mixture of 3d
and 3d')
31 (mixture of 3e
and 3e')
34
H
H
COPh
Cl
N
N
H
O
N
H
O
1i
1h
N
N
Ph
Yield (%)
3h 50
Yield (%)
3i 37
Ph
Scheme 1
Diamines with symmetrical structure (1a, 1f, and 1g) afforded one product (3a, 3f, and 3g) in their
reactions. One product was also obtained in reactions with unsymmetrical diamines 1b, 1h and 1i. In the
case of unsymmetrical o-phenylenediamines 1ce, mixtures of the corresponding isomers (3c/c’, 3d/d’,
and 3e/e’) were isolated with the spiro compounds 3c, 3d or 3e as the major and 3c’, 3d’ or 3e’ as the
minor isomers. The ratios between the major and minor isomer in the crude product mixtures, established
1
on the basis of H NMR spectra of the isolated products, were 6:1 for 3c/c’, 2:1 for 3d/d’, and 13:1 for
3e/e’ pair. Our attempts to completely separate the spirooxazoline isomers by crystallization or
chromatographic techniques failed although crystallization increased the amount of the major component
in these pairs giving ratios of 7:1 (3c/c’), 3:1 (3d/d’), and 33:1 (3e/e’), respectively.

HETEROCYCLES, Vol. 83, No. 10, 2011
2355
1
The structural assignments of compounds 3af were mainly carried out by H, 13C, and 2D NMR
1
spectroscopy. H NMR spectra of these spiro compounds exhibited two doublets at 4.244.36 and
13
5.115.22 ppm for CH2 protons of the oxazoline ring with coupling constants of 9.09.8 Hz. Their C
NMR spectra showed the spiro carbon atoms at 8485 ppm. Structures of the spiro products obtained in
reactions with unsymmetrical diamines were determined on the basis of HMBC correlations between NH
protons in the dihydropyrazinone system and carbon atoms in the adjacent fused ring.
Structure and ratio of products obtained in reactions with unsymmetrical diamines indicate that the more
basic amino group predominantly reacts with the α-carbon atom of the starting acid 2 and the less basic
amino group with the carboxylic group. This transformation probably starts with an attack of the amino
group to the acid tautomeric imine form 2a giving intermediate A which then cyclises into the oxazoline
intermediate B followed by the formation of the pyrazinone system (Scheme 2). Such reaction sequence
is supported by a conversion of the acid 2 into benzamide via 2a,7 an easy approach to oxazolines by
cyclization of β-haloamides,8 and generally known unsuitableness of the preparation of amides by
treatment of carboxylic acids with amines.
HO2C
PhOCN
Cl
2a
NH2
H
N
NH2
NH2
NH2
N
O
CO2H
O
CO2H
Cl
NHCOPh
N
H
O
H
N
H
N
N
1
A
Ph
Ph
B
3
Scheme 2
In order to get insight into the reactivity of these spiro products, we began with alkylation reactions of 3.
Heating of 3a with N,N-dimethylformamide dimethyl acetale in toluene introduced one methyl group on
the lactam nitrogen atom in the pyrazinone part giving 4a in 34% yield. Low yield of 4a was also
obtained with dimethyl sulphate and NaOH in acetonitrile (25%). On the other hand, better results were
obtained by treatment with methyl iodide, using Bu4NHSO4 as a catalyst and an excess of K2CO3 at 80 oC,
giving 4a in 79% yield. An alternative approach to the synthesis of 4a, heating of N-methyl substituted
diamine 7 with 2 under standard conditions for the formation of the spirooxazolines 13, afforded 4a in
28% yield. Taking into account these results, 5a was prepared from 3a with ethyl bromide in the presence
of Bu4NHSO4 and K2CO3 in 88% yield. Applying 1,2-dibromoethane or 1,2-dichloroethane as the
alkylation reagent, 2-hydroxyethyl derivative 6a was synthesized in 65 and 51% yield, respectively
(Scheme 3).

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HETEROCYCLES, Vol. 83, No. 10, 2011
Me
N
H
N
MeI, MeCN
K2CO3, Bu4NHSO4,
O
 
O
 
 
or Me2NCH(OMe)2, toluene,
N
H
O
N
H
O
or Me2SO4, NaOH, MeCN,
ClCH2CH2Cl, MeCN
N
N
3a
4a
Ph
Ph
K2CO3, Bu4NHSO4,  
EtBr, MeCN
K2CO 3, Bu4NHSO4
 
2, Et3N
 
EtOH,
or BrCH2CH2Br, MeCN
 
K2CO3, Bu4NHSO4,
Et
N
OH
N
O
O
NHMe
N
O
N
H
O
N
H
NH2
N
6a
5a
7
Ph
Ph
Scheme 3
With these results in hand, using the same alkylation procedure with methyl iodide or ethyl bromide, we
prepared other N-alkyl derivatives of spirooxazolines in 19-84% yields. Methylation of mixtures of 3c/c’
and 3d/d’ afforded mixtures of the corresponding methyl derivatives 4c/c’ and 4d/d’. Ethylation of 3d/d’
gave a mixture of the corresponding ethyl derivatives 5d/d’. On the other hand, ethylation of 3c/c’
afforded only one isomer, compound 5c (Figure 1).
R
R1
R
N
R
N
R2
R3
O
O
N
N
O
N
H
O
N
H
O
N
H
O
N
N
N
Ph
R2 R3
Ph
Ph
R
R1
R
Yield (%)
R
Yield (%)
Yield (%)
4g
5g
4c
4c' Me
4d Me
4d' Me
Me
H
Me 57
Et 69
4h Me
5h Et
H
H
H
H
H
NO2 84 (mixture of 4c
71
66
NO2
Cl
H
H
H
Cl
Cl
and 4c')
69 (mixture of 4d
and 4d')
Et
N
N
O
4f
Me
Cl
72
N
5c
5d
5d' Et
5f Et
Et
Et
H
H
H
H
H
Cl
H
NO2 60
N
H
O
H
Cl
Cl
28 (mixture of 5d
and 5d')
N
Yield (%)
5i 19
Ph
Cl
81
Figure 1
In summary, we described the synthesis of several spiro-2-oxazolines and their alkylation. This work
represents a novel contribution to the synthesis of heterocyclic spiro compounds9 as well as a new
confirmation of a great diversity of the use of various dehydroamino acid derivatives in heterocyclic
synthesis.

HETEROCYCLES, Vol. 83, No. 10, 2011
2357
EXPERIMENTAL
Melting points were determined on a Kofler micro hot stage. NMR spectra were recorded on a Bruker
AVANCE DPX-300 spectrometer (300 MHz for 1H and 75.5 MHz for 13C) in DMSO-d6 with TMS as an
internal standard. MS spectra were obtained on a VG-Analytical AutoSpec Q instrument. Elemental
analyses were performed on a Perkin-Elmer CHN Analyzer 2400. TLC was carried out on Fluka silica gel
TLC-cards. Radial chromatography was performed on Merck Kieselgel PF254 silica gel. Compound 2 was
prepared as described in the literature.7 All other compounds were used without purification as obtained
from commercial sources.
5’-Nitro-2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (3b). Typical Procedure A: To
a mixture of 3-nitrobenzen-1,2-diamine (1b) (153 mg, 1 mmol), 2-benzoylamino-3-chloropropenoic acid
(2) (226 mg, 1 mmol) and EtOH (4 mL), Et3N (160 mg, 1.6 mmol) was added. The reaction mixture was
heated under reflux for 6.5 h. Upon cooling to rt, the precipitate was filtered off and washed with EtOH to
give 3b (54 mg, 17%). mp 222224 °C (MeOH). 1H NMR : 4.36 (d, 1H, J = 9.8 Hz, CH2), 5.18 (d, 1H, J
= 9.8 Hz, CH2), 7.10 (deg. dd, 1H, J = 7.9, 7.9 Hz, H7’), 7.17 (dd, 1H, J = 1.5, 7.9 Hz, H8’), 7.447.51
(m, 2H, Ph), 7.557.62 (m, 2H, 1H of Ph, H6’), 7.847.89 (m, 3H, 2H of Ph, NH), 10.43 (s, 1H, NHCO).
13C NMR : 72.6, 83.9, 115.0, 119.7, 120.6, 122.9, 126.2, 128.3, 128.8, 132.5, 134.6, 135.0, 163.9, 164.2.
MS (EI, m/z, %): 324 (M+, 35). Anal. Calcd for C16H12N4O4: C, 59.26; H, 3.73; N, 17.28. Found: C,
59.19; H, 3.69; N, 17.09.
7’-Nitro-2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (3c) and 6’-Nitro-2-phenyl-
1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (3c’). Following the typical procedure A, treatment
of diamine 1c (153 mg, 1.0 mmol), with acid 2 (226 mg, 1.0 mmol) and Et3N (160 mg, 1.6 mmol) in
EtOH (4 mL) gave a mixture of 3c (major isomer) and 3c’ (minor isomer) (149 mg, 46%) in a ratio of
6:1; crystallization from EtOH gave a ratio of 7:1. 1H NMR  (3c): 4.32 (d, 1H, J = 9.6 Hz, CH2), 5.16 (d,
1H, J = 9.6 Hz, CH2), 7.06 (d, 1H, J = 8.7 Hz, H5’), 7.447.51 (m, 2H, Ph), 7.567.62 (m, 2H, 1H of Ph,
H8’), 7.71 (dd, 1H, J = 2.6, 8.7 Hz, H6’), 7.79 (s, 1H, NH), 7.847.89 (m, 2H, Ph), 11.42 (s, 1H, NHCO).
1H NMR  (3c’): 4.37 (d, 1H, J = 9.6 Hz, CH2), 5.15 (d, 1H, J = 9.6 Hz, CH2), 6.86 (d, 1H, J = 9.0 Hz,
H8’), 7.447.51 (m, 2H, Ph), 7.567.62 (m, 1H, Ph), 7.77 (d, 1H, J = 2.3 Hz, H5’), 7.837.89 (m, 3H,
H7’, 2H of Ph), 8.38 (s, 1H, NH), 11.20 (s, 1H, NHCO). 13C NMR  (3c): 72.9, 84.2, 108.4, 114.8, 115.1,
126.2, 128.2, 128.8, 131.7, 132.4, 142.6, 163.8, 164.5. MS (FAB, m/z, %) (3c/c’): 325 (MH+, 61). Anal.
Calcd for C16H12N4O4 (3c/c’): C, 59.26; H, 3.73; N, 17.28. Found: C, 59.18; H, 3.51; N, 17.54.
6’-Chloro-2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (3d) and 7’-Chloro-2-
phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (3d’). Following the typical procedure A,
treatment of diamine 1d (71 mg, 0.5 mmol) with acid 2 (113 mg, 0.5 mmol) and Et3N (80 mg, 0.8 mmol)

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HETEROCYCLES, Vol. 83, No. 10, 2011
in EtOH (2 mL) gave a mixture of 3d (major isomer) and 3d’ (minor isomer) (31 mg, 20%) in a ratio of
2:1; crystallization from EtOH gave a ratio of 3:1. 1H NMR  (3d): 4.25 (d, 1H, J = 9.0 Hz, CH2), 5.10 (d,
1H, J = 9.0 Hz, CH2), 6.74 (d, 1H, J = 9.4 Hz, H8’), 6.886.92 (m, 2H, H5’, H7’), 7.33 (s, 1H, NH),
7.437.51 (m, 2H, Ph), 7.567.62 (m, 1H, Ph), 7.827.88 (m, 2H, Ph), 10.88 (s, 1H, NHCO). 1H NMR 
(3d’): 4.26 (d, 1H, J = 9.4 Hz, CH2), 5.11 (d, 1H, J = 9.4 Hz, CH2), 6.736.80 (m, 2H, H6’, H8’), 6,86 (d,
1H, J = 8.3 Hz, H5’), 7.40 (s, 1H, NH), 7.437.51 (m, 2H, Ph), 7.567.62 (m, 1H, Ph), 7.827.88 (m, 2H,
Ph), 10.88 (s, 1H, NHCO). MS (FAB, m/z, %) (3d/d’): 314 (MH+, 100). Anal. Calcd for C16H12ClN3O2
(3d/d’): C, 61.25; H, 3.86; N, 13.39. Found: C, 61.29; H, 3.61; N, 13.62.
7’-Benzoyl-2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (3e) and 6’-Benzoyl-2-
phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (3e’). Following the typical procedure A,
treatment of diamine 1e (212 mg, 1.0 mmol) with acid 2 (226 mg, 1.0 mmol) and Et3N (160 mg, 1.6
mmol) in EtOH (4 mL) gave a mixture of 3e (major isomer) and 3e’ (minor isomer) (118 mg, 31%) in a
1
ratio of 13:1; crystallization from EtOH gave a ratio of 33:1. H NMR  (3e): 4.27 (d, 1H, J = 9.4 Hz,
CH2), 5.15 (d, 1H, J = 9.6 Hz, CH2), 7.02 (d, 1H, J = 7.9, H5’), 7.187.24 (m, 2H, H6’, H8’), 7.437.72
(m, 9H, 8H of Ph, NH), 7.837.89 (m, 2H, Ph), 11.18 (s, 1H, NHCO). 1H NMR  (3e’): 6.85 (d, 1H, J =
8.3, H8’), 7.35 (dd, 1H, J = 1.9, 8.3 Hz, H7’), 7.97 (s, 1H, NH), 10.96 (s, 1H, NHCO). 13C NMR  (3e):
72.9, 84.6, 114.5, 115.2, 121.9, 126.5, 128.2, 128.3, 128.7, 129.1, 129.9, 131.5, 131.9, 132.0, 132.3, 137.9,
163.5, 164.6, 194.7. MS (EI, m/z, %) (3e/e’): 383 (M+, 15). Anal. Calcd for C23H17N3O3 (3e/e’): C, 72.05;
H, 4.47; N, 10.96. Found: C, 71.94; H, 4.37; N, 10.81.
6’,7’-Dichloro-2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (3f). Following the
typical procedure A, treatment of diamine 1f (89 mg, 0.5 mmol) with acid 2 (113 mg, 0.5 mmol) and Et3N
(80 mg, 0.8 mmol) in EtOH (2 mL) gave 3f (60 mg, 34%). mp 252254 °C (EtOH). 1H NMR : 4.28 (d,
1H, J = 9.4 Hz, CH2), 5.11 (d, 1H, J = 9.4 Hz, CH2), 6.90 (s, 1H, H8’), 7.03 (s, 1H, H5’), 7.447.62 (m,
4H, 3H of Ph, NH), 7.827.88 (m, 2H, Ph), 11.00 (s, 1H, NHCO). MS (EI, m/z, %): 347 (M+, 38). Anal.
Calcd for C16H11Cl2N3O2: C, 55.19; H, 3.18; N, 12.07. Found: C, 54.87; H, 3.25; N, 11.80.
2’-Phenyl-1H,5’H-spiro[benzo[g]quinoxaline-2,4’-oxazole]-3(4H)-one (3g). Following the typical
procedure A, treatment of diamine 1g (158 mg, 1.0 mmol) with acid 2 (226 mg, 1.0 mmol) and Et3N (160
mg, 1.6 mmol) in EtOH (4 mL), gave 3g (91 mg, 28%). mp 284285 °C (DMFEtOH). 1H NMR : 4.34
(d, 1H, J = 9.4 Hz, CH2), 5.16 (d, 1H, J = 9.4 Hz, CH2), 7.10 (s, 1H, H10), 7.207.31 (m, 3H, H5, H7,
H8), 7.427.51 (m, 3H, 2 H of Ph, NH), 7.547.61 (m, 1H, Ph), 7.617.71 (m, 2H, H6, H9), 7.827.87
(m, 2H, Ph), 11.11 (s, 1H, NHCO). MS (EI, m/z, %): 329 (M+, 73). Anal. Calcd for C20H15N3O2: C, 72.94;
H, 4.59; N, 12.76. Found: C, 72.91; H, 4.73; N, 12.93.

HETEROCYCLES, Vol. 83, No. 10, 2011
2359
2-Phenyl-1’H,5H-spiro[oxazole-4,2’-pyrido[3,2-b]pyrazin]-3’(4’H)-one (3h). Following the typical
procedure A, treatment of diamine 1h (55 mg, 0.5 mmol) with acid 2 (113 mg, 0.5 mmol) and Et3N (80
mg, 0.8 mmol) in EtOH (2 mL) gave 3h (70 mg, 50%). mp 265266 °C (DMFMeOH). 1H NMR : 4.29
(d, 1H, J = 9.4 Hz, CH2), 5.13 (d, 1H, J = 9.4 Hz, CH2), 6.91 (dd, 1H, J = 4.9, 7.9 Hz, H7’), 7.09 (dd, 1H,
J = 1.5, 7.9 Hz, H8’), 7.38 (s, 1H, NH), 7.437.50 (m, 2H, Ph), 7.557.61 (m, 1H, Ph), 7.74 (dd, 1H, J =
13
1.5, 4.9 Hz, H6’), 7.837.88 (m, 2H, Ph), 11.24 (s, 1H, NHCO). C NMR : 72.8, 84.7, 118.9, 120.1,
126.5, 128.0, 128.2, 128.7, 132.3, 137.4, 140.0, 163.5, 165.2. MS (EI, m/z, %): 280 (M+, 56). Anal. Calcd
for C15H12N4O2: C, 64.28; H, 4.32; N, 19.99. Found: C, 63.92; H, 4.02; N, 20.04.
2-Phenyl-5H,5’H-spiro[oxazole-4,6’-pteridin]-7’(8’H)-one (3i). Following the typical procedure A,
treatment of diamine 1i (55 mg, 0.5 mmol) with acid 2 (113 mg, 0.5 mmol) and Et3N (80 mg, 0.8 mmol)
1
in EtOH (2 mL) gave 3i (52 mg, 37%). mp 246248 °C (EtOH). H NMR : 4.33 (d, 1H, J = 9.6 Hz,
CH2), 5.14 (d, 1H, J = 9.6 Hz, CH2), 7.447.51 (m, 2H, Ph), 7.567.65 (m, 2H, 1H of Ph, NH), 7.847.89
(m, 2H, Ph), 8.08 (s, 1H, H4’), 8.36 (s, 1H, H2’), 11.74 (s, 1H, NHCO). MS (EI, m/z, %): 281 (M+, 46).
Anal. Calcd for C14H11N5O2: C 59.78; H, 3.94; N, 24.90. Found: C, 59.49; H, 3.72; N, 25.01.
4’-Methyl-2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (4a). From 3a using methyl
iodide. Typical Procedure B: To a mixture of spiro compound 3a (140 mg, 0.5 mmol) and MeCN (5 mL),
K2CO3 (690 mg, 5 mmol), Bu4NHSO4 (34 mg, 0.1 mmol), and MeI (0.13 mL, 2.1 mmol) were added.
The reaction mixture was stirred at 80 °C for 6 h. Upon cooling to rt, the solid was filtered off and
washed with MeCN (2 x 3 mL). The collected filtrate was evaporated under reduced pressure, the solid
residue was suspended in MeOH (1 mL), filtered off and washed with MeOH to give 4a (116 mg, 79%).
mp 210-215 °C (MeOH). 1H NMR : 3.37 (s, 3H, Me), 4.27 (d, 1H, J = 9.2 Hz, CH2), 5.17 (d, 1H, J = 9.2
Hz, CH2), 6.81 (dd, 1H, J = 1.5, 7.9 Hz, H8’), 6.86 (ddd, 1H, J = 1.5, 7.5, 7.9 Hz, H6’), 6.96 (ddd, 1H, J
= 1.5, 7.5, 7.9 Hz, H7’), 7.097.14 (m, 1H, H5’), 7.25 (s, 1H, NH), 7.417.48 (m, 2H, Ph), 7.537.60 (m,
13
1H, Ph), 7.807.86 (m, 2H, Ph). C NMR : 29.2, 73.4, 85.0, 114.2, 114.7, 119.0, 123.4, 126.6, 127.8,
128.2, 128.7, 132.2, 133.2, 163.5, 164.0. MS (EI, m/z, %): 293 (M+, 78). Anal. Calcd for C17H15N3O2: C,
69.61; H, 5.15; N, 14.33. Found: C, 69.60; H, 5.17; N, 14.40.
From 3a using dimethyl sulphate: To a mixture of spiro compound 3a (98 mg, 0.35 mmol), Me2SO4 (65
mg, 0.5 mmol), and MeCN (2 mL), 33% NaOH was added until pH exceeded 8. The reaction mixture
was then heated under reflux for 1.5 h. Upon cooling to rt, diluted H2SO4 (1:4) was added until pH = 6.5.
Extraction with AcOEt (2 x 5 mL) gave the crude solid, which was suspended in MeOH (1 mL). The
precipitated solid was filtered off and washed with MeOH to give 4a (26 mg, 25%).
From 3a using N,N-dimethylformamide dimethyl acetal. A mixture of spiro compound 3a (140 mg, 0.5
mmol), N,N-dimethylformamide dimethyl acetal (179 mg, 1.5 mmol), and toluene (2 mL) was heated

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under reflux for 8.5 h. The volatile compounds were then removed under reduced pressure and the solid
residue was suspended in MeOH (1 mL), filtered off, washed with MeOH and crystallized from EtOH to
give 4a (50 mg, 34%).
From N-methylbenzene-1,2-diamine and 2: To a mixture of N-methylbenzene-1,2-diamine (7) (249 mg, 2
mmol) and acid 2 (451 mg, 2 mmol) in EtOH (8 mL), Et3N (320 mg, 3.2 mmol) was added. The reaction
mixture was then heated under reflux for 7 h. The volatile compounds were removed under reduced
pressure, the residue was suspended in EtOH (2 mL), filtered off and washed with EtOH to give 4a (166
mg, 28%).
4’-Methyl-7’-nitro-2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (4c) and 4’-Methyl-
6’-nitro-2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (4c’). Following the typical
procedure B, treatment of a mixture of spiro compounds 3c and 3c’ (ratio 6:1) (113 mg, 0.35 mmol) with
K2CO3 (483 mg, 3.4 mmol), Bu4NHSO4 (24 mg, 0.07 mmol) and MeI (0.09 mL, 1.4 mmol) in MeCN (4
mL) gave a mixture of 4c (major isomer) and 4c’ (minor isomer) (99 mg, 84%); crystallization from
DMFMeOH gave a ratio of 14:1. 1H NMR  (4c): 3.46 (s, 3H, Me), 4.33 (d, 1H, J = 9.8 Hz, CH2), 5.21
(d, 1H, J = 9.8 Hz, CH2), 7.35 (d, 1H, J = 8.9 Hz, H5’), 7.437.50 (m, 2H, Ph), 7.557.62 (m, 1H, Ph),
7.63 (d, 1H, J = 2.6 Hz, H8’), 7.78 (dd, 1H, J = 2.6, 8.9 Hz, H6’), 7.817.86 (m, 2H, Ph), 7.79 (s, 1H,
1
NH). H NMR  (4c’): 3.48 (s, 3H, Me), 4.38 (d, 1H, J = 9.4 Hz, CH2), 5.20 (d, 1H, J = 9.4 Hz, CH2),
6.92 (d, 1H, J = 9.0 Hz, H8’), 8.49 (s, 1H, NH). MS (EI, m/z, %) (4c/c’): 338 (M+, 91). Anal. Calcd for
C17H14N4O4 (4c/c’): C, 60.35; H, 4.17; N, 16.56. Found: C, 60.31; H, 4.06; N, 16.36.
6’-Chloro-4’-methyl-2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (4d) and 7’-
Chloro-4’-methyl-2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one
(4d’).
Typical
Procedure C: To a mixture of spiro compounds 3d and 3d’ (ratio 2:1) (110 mg, 0.35 mmol) in MeCN (4
mL), K2CO3 (483 mg, 3.4 mmol), Bu4NHSO4 (24 mg, 0.07 mmol), and MeI (0.09 mL, 1.4 mmol) were
added. The reaction mixture was then stirred at 80 °C for 7 h. Upon cooling to rt, the solid was filtered off,
washed with MeCN (2 x 3 mL) and suspended in water (2 mL). The insoluble residue was filtered off and
washed with water to give pure 4d (35 mg, 30%). mp 245-248 °C (EtOHMeOH). The collected filtrate
obtained by first filtration was evaporated under reduced pressure, the residue was suspended in MeOH (1
mL), filtered off and washed with MeOH to give a mixture of 4d (minor isomer) and 4d’ (major isomer)
1
(45 mg, 39%); crystallization from MeOHEtOH gave a mixture of 4d/4d’ in a ratio of 1:5. H NMR 
(4d): 3.37 (s, 3H, Me), 4.28 (d, 1H, J = 9.4 Hz, CH2), 5.17 (d, 1H, J = 9.4 Hz, CH2), 6.80 (d, 1H, J = 8.7
Hz, H8’), 7.00 (dd, 1H, J = 2.3, 8.7 Hz, H7’), 7.19 (d, 1H, J = 2.3 Hz, H5’), 7.417.49 (m, 3H, 2 H of Ph,
NH), 7.547.61 (m, 1H, Ph), 7.807.86 (m, 2H, Ph). 1H NMR  (4d’): 3.36 (s, 3H, Me), 4.28 (d, 1H, J =
9.4 Hz, CH2), 5.18 (d, 1H, J = 9.4 Hz, CH2), 6.80 (d, 1H, J = 2.3 Hz, H8’), 6.89 (dd, 1H, J = 2.3, 8.7 Hz,

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H6’), 7.13 (d, 1H, J = 8.7 Hz, H5’), 7.427.49 (m, 2H, Ph), 7.51 (s, 1H, NH), 7.557.61 (m, 1H, Ph),
7.807.86 (m, 2H, Ph). MS (FAB, m/z, %) (4d): 328 (MH+, 8). Anal. Calcd for C17H14ClN3O2 (4d): C,
62.30; H, 4.31; N, 12.82. Found: C, 61.94; H, 4.17; N, 12.50.
6’,7’-Dichloro-4’-methyl-2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one
(4f).
Following the typical procedure C, treatment of spiro compound 3f (122 mg, 0.35 mmol) with K2CO3
(966 mg, 7 mmol), Bu4NHSO4 (48 mg, 0.14 mmol) and MeI (0.18 mL, 2.9 mmol) in MeCN (6 mL) gave
1
4f (91 mg, 72%). mp 238243 °C (DMFMeOH). H NMR : 3.38 (s, 3H, Me), 4.30 (d, 1H, J = 9.8 Hz,
CH2), 5.17 (d, 1H, J = 9.8 Hz, CH2), 6.95 (s, 1H, H8’), 7.37 (s, 1H, H5’), 7.437.50 (m, 2H, Ph),
7.557.62 (m, 1H, Ph), 7.63 (s, 1H, NH), 7.817.86 (m, 2H, Ph). MS (EI, m/z, %): 361 (M+, 68). Anal.
Calcd for C17H13Cl2N3O2: C, 56.37; H, 3.62; N, 11.60. Found: C, 56.17; H, 3.58; N, 11.43.
4-Methyl-2’-phenyl-1H,5’H-spiro[benzo[g]quinoxaline-2,4’-oxazole]-3(4H)-one (4g). Following the
typical procedure C, treatment of spiro compound 3g (115 mg, 0.35 mmol) with K2CO3 (966 mg, 7
mmol), Bu4NHSO4 (48 mg, 0.14 mmol) and MeI (0.18 mL, 2.9 mmol) in MeCN (6 mL) gave 4g (68 mg,
57%). mp 248252 °C dec. (DMFMeOH). 1H NMR : 3.51 (s, 3H, Me), 4.36 (d, 1H, J = 9.4 Hz, CH2),
5.21 (d, 1H, J = 9.4 Hz, CH2), 7.15 (s, 1H, H10), 7.257.37 (m, 2H, H7, H8), 7.417.47 (m, 2H, Ph),
7.537.69 (m, 4H, 1H of Ph, H6, H9, NH), 7.797.85 (m, 3H, 2H of Ph, H5). MS (EI, m/z, %): 343 (M+,
83). Anal. Calcd for C21H17N3O2: C, 73.45; H, 4.99; N, 12.24. Found: C, 73.29; H, 5.29; N, 12.27.
4’-Methyl-2-phenyl-1’H,5H-spiro[oxazole-4,2’-pyrido[3,2-b]pyrazin]-3’(4’H)-one (4h). Following
the typical procedure B, treatment of spiro compound 3h (98 mg, 0.35 mmol) with K2CO3 (966 mg, 7
mmol), Bu4NHSO4 (48 mg, 0.14 mmol) and MeI (0.18 mL, 2.9 mmol) in MeCN (6 mL) gave 4h (73 mg,
71%). mp 225228 °C (MeOH). 1H NMR : 3.44 (s, 3H, Me), 4.31 (d, 1H, J = 9.4 Hz, CH2), 5.19 (d, 1H,
J = 9.4 Hz, CH2), 7.00 (dd, 1H, J = 4.9, 7.9 Hz, H7’), 7.14 (dd, 1H, J = 1.5, 7.9 Hz, H8’), 7.437.52 (m,
3H, 2H of Ph, NH), 7.557.61 (m, 1H, Ph), 7.827.89 (m, 3H, H6’, 2H of Ph). MS (EI, m/z, %): 294 (M+,
100). Anal. Calcd for C16H14N4O2: C, 65.30; H, 4.79; N, 19.04. Found: C, 65.24; H, 4.88; N, 18.95.
4’-Ethyl-7’-nitro-2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (5c). Following the
typical procedure B, treatment of a mixture of spiro compounds 3c and 3c’ (ratio 6:1) (113 mg, 0.35
mmol) with, K2CO3 (725 mg, 5.25 mmol), Bu4NHSO4 (36 mg, 0.11 mmol) and EtBr (0.16 mL, 2.1
mmol) in MeCN (4 mL) for 3h gave only isomer 5c (73 mg, 60%). mp 226231 °C (EtOH). 1H NMR :
1.18 (t, 3H, J = 7.0 Hz, CH2CH3), 4.034.16 (m, 2H, CH2CH3), 4.33 (d, 1H, J = 9.8 Hz, CH2), 5.22 (d, 1H,
J = 9.8 Hz, CH2), 7.387.50 (m, 3H, 2H of Ph, H5’), 7.557.62 (m, 1H, Ph), 7.65 (d, 1H, J = 2.6 Hz, H8’),
7.76 (dd, 1H, J = 2.6, 9.1 Hz, H6’), 7.817.87 (m, 2H, Ph), 7.89 (s, 1H, NH). MS (EI, m/z, %): 352 (M+,
73). Anal. Calcd for C18H16N4O4: C, 61.36; H, 4.58; N, 15.90. Found: C, 61.21; H, 4.94; N, 15.89.

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6’-Chloro-4’-ethyl-2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (5d) and 7’-Chloro-
4’-ethyl-2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (5d’). Following the typical
procedure B, treatment of a mixture of spiro compounds 3d/d’ (ratio 2:1) (110 mg, 0.35 mmol) with,
K2CO3 (725 mg, 5.25 mmol), Bu4NHSO4 (36 mg, 0.11 mmol) and EtBr (0.16 mL, 2.1 mmol) in MeCN (4
mL) for 3h gave a crude mixture of 5d/d’; crystallization from EtOH gave a mixture of 5d (major isomer)
and 5d’ (minor isomer) (34 mg, 28%) in a ratio of 3:1. 1H NMR  (5d): 1.13 (t, 3H, J = 7.0 Hz, CH2CH3),
4.01 (q, 2H, J = 7.0 Hz, CH2CH3), 4.27 (d, 1H, J = 9.4 Hz, CH2), 5.18 (d, 1H, J = 9.4 Hz, CH2), 6.81 (d,
1H, J = 8.3 Hz, H8’), 6.99 (dd, 1H, J = 2.3, 8.3 Hz, H7’), 7.22 (d, 1H, J = 2.3 Hz, H5’), 7.41 (s, 1H, NH),
7.42 7.49 (m, 2H, Ph), 7.547.61 (m, 1H, Ph), 7.807.86 (m, 2H, Ph). 1H NMR  (5d’): 1.13 (t, 3H, J =
7 Hz, CH2CH3), 4.0 (q, 2H, J = 7.0 Hz, CH2CH3), 4.27 (d, 1H, J = 9.4 Hz, CH2), 5.18 (d, 1H, J = 9.4 Hz,
CH2), 6.81 (d, 1H, J = 2.3 Hz, H8’), 6.88 (dd, 1H, J = 2.3, 8.7 Hz, H6’), 7.17 (d, 1H, J = 8.7 Hz, H5’),
7.427.49 (m, 3H, 2H of Ph, NH), 7.547.61 (m, 1H, Ph), 7.807.86 (m, 2H, Ph). MS (EI, m/z, %)
(5d/d’): 341 (M+, 66). Anal. Calcd for C18H16ClN3O2 (5d/d’): C, 63.25; H, 4.72; N, 12.29. Found: C,
62.87; H, 4.69; N, 12.14.
6’,7’-Dichloro-4’-ethyl-2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (5f). Following
the typical procedure B, treatment of spiro compound 3f (122 mg, 0.35 mmol) with K2CO3 (7.25 mg, 5.25
mmol), Bu4NHSO4 (36 mg, 0.11 mmol) and EtBr (0.16 mL, 2.1 mmol) in MeCN (4 mL) for 2h gave 5f
(107 mg, 81%). mp 215216 °C (EtOH). 1H NMR : 1.13 (t, 3H, J = 7.1 Hz, CH2CH3), 4.02 (q, 2H, J =
7.1 Hz, CH2CH3), 4.29 (d, 1H, J = 9.6 Hz, CH2), 5.18 (d, 1H, J = 9.6 Hz, CH2), 6.97 (s, 1H, H8’), 7.41 (s,
1H, H5’), 7.437.50 (m, 2H, Ph), 7.557.63 (m, 2H, NH, 1H of Ph), 7.817.86 (m, 2H, Ph). MS (EI,
m/z, %): 375 (M+, 73). Anal. Calcd for C18H15Cl2N3O2: C, 57.46; H, 4.02; N, 11.17. Found: C, 57.50; H,
4.19; N, 10.86.
4-Ethyl-2’-phenyl-1H,5’H-spiro[benzo[g]quinoxaline-2,4’-oxazole]-3(4H)-one (5g). Following the
typical procedure B, treatment of spiro compound 3g (115 mg, 0.35 mmol) with K2CO3 (725 mg, 5.25
mmol), Bu4NHSO4 (36 mg, 0.11 mmol) and EtBr (0.16 mL, 2.1 mmol) in MeCN (4 mL) for 7.5h gave 5g
(after double crystallization: 86 mg, 69%). mp 247249 °C (EtOH). 1H NMR : 1.24 (br t, 3H, J = 7.0 Hz,
CH2CH3), 4.14 (br q, 2H, J = 7.0 Hz, CH2CH3), 4.35 (d, 1H, J = 9.2 Hz, CH2), 5.22 (d, 1H, J = 9.2 Hz,
CH2), 7.15 (s, 1H, H10), 7.237.86 (m, 11H, NH, H5, H6, H7, H8, H9, 5H of Ph). MS (EI, m/z, %): 357
(M+, 100). Anal. Calcd for C22H19N3O2: C, 73.93; H, 5.36; N, 11.76. Found: C, 74.11; H, 5.61; N, 11.84.
4’-Ethyl-2-phenyl-1’H,5H-spiro[oxazole-4,2’-pyrido[3,2-b]pyrazin]-3’(4’H)-one (5h). Following the
typical procedure B, treatment of spiro compound 3h (98 mg, 0.35 mmol) with K2CO3 (725 mg, 5.25
mmol), Bu4NHSO4 (36 mg, 0.11 mmol) and EtBr (0.16 mL, 2.1 mmol) in MeCN (4 mL) for 7h gave 5h
(71 mg, 66%). mp 201203 °C (EtOH). 1H NMR : 1.15 (t, 3H, J = 7.0 Hz, CH2CH3), 4.024.30 (m, 2H,

HETEROCYCLES, Vol. 83, No. 10, 2011
2363
CH2CH3), 4.30 (d, 1H, J = 9.4 Hz, CH2), 5.19 (d, 1H, J = 9.4 Hz, CH2), 7.00 (dd, 1H, J = 4.9, 7.9 Hz,
H7’), 7.14 (dd, 1H, J = 1.5, 7.9 Hz, H8’), 7.437.50 (m, 3H, 2H of Ph, NH), 7.557.61 (m, 1H, Ph),
7.827.89 (m, 3H, 2H of Ph, H6’). MS (EI, m/z, %): 308 (M+, 100). Anal. Calcd for C17H16N4O2: C,
66.22; H, 5.23; N, 18.17. Found: C, 66.08; H, 5.38; N, 18.06.
4’-Ethyl-2-phenyl-5H,5’H-spiro[oxazole-4,6’-pteridin]-7’(8’H)-one (5i). Following the typical
procedure B, treatment of spiro compound 3i (98 mg, 0.35 mmol) with K2CO3 (7.25 mg, 5.25 mmol),
Bu4NHSO4 (36 mg, 0.11 mmol) and EtBr (0.16 mL, 2.1 mmol) in MeCN (4 mL) for 5 h afforded 5i (after
crystallization from EtOH: 20 mg, 19%). mp 189194 °C. 1H NMR : 1.17 (t, 3H, J = 7.2 Hz, CH2CH3),
4.014.07 (m, 2H, CH2CH3), 4.36 (d, 1H, J = 9.6 Hz, CH2), 5.21 (d, 1H, J = 9.6 Hz, CH2), 7.447.50 (m,
2H, Ph), 7.577.63 (m, 1H, Ph), 7.76 (s, 1H, NH), 7.837.88 (m, 2H, Ph), 8.14 (s, 1H, H4’), 8.50 (s, 1H,
H2’). MS (EI, m/z, %): 309 (M+, 59). Anal. Calcd for C16H15N5O2: C 62.13; H, 4.89; N, 22.64. Found: C,
61.83; H, 5.21; N, 22.83.
4’-(2-Hydroxyethyl)-2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (6a). From 3a and
1,2-dibromoethane: To a mixture of spiro compound 3a (140 mg, 0.5 mmol) and MeCN (10 mL), K2CO3
(1.38 g, 10 mmol), Bu4NHSO4 (68 mg, 0.2 mmol), and 1,2-dibromoethane (0.86 mL, 10 mmol) were
added. The reaction mixture was then stirred at 80 °C for 10.5 h. Upon cooling to rt, the solid was filtered
off and washed with MeCN (2 x 4 mL). The collected filtrate was evaporated under reduced pressure and
the oily residue was purified by radial chromatography (CHCl3, MeOH 50:1) to give 6a (105 mg, 65%).
From 3a and 1,2-dichloroethane: To a mixture of 3a (98 mg, 0.35 mmol) and MeCN (5 mL), K2CO3 (966
mg, 7 mmol), Bu4NHSO4 (48 mg, 0.14 mmol) and 1,2-dichloroethane (0.55 mL, 10 mmol) were added.
The reaction mixture was then stirred at 80 °C for 9 h. Upon cooling to rt, the solid was filtered off and
washed with MeCN (2 x 2 mL). The collected filtrate was evaporated under reduced pressure and the oily
residue was purified by radial chromatography (CHCl3, MeOH 50:1) to give 6a (58 mg, 51%). mp
1
227230 °C (EtOH). H NMR : 3.503.61 (m, 2H, CH2OH), 4.04 (br t, 2H, J = 6.8 Hz, CH2CH2OH),
4.26 (d, 1H, J = 9.0 Hz, CH2), 4.88 (t, 1H, J = 5.5 Hz, CH2OH, 5.17 (d, 1H, J = 9.0 Hz, CH2), 6.786.97
(m, 3H, H6’, H7’, H8’), 7.197.24 (m, 2H, H5’, NH), 7.427.48 (m, 2H, Ph), 7.547.60 (m, 1H, Ph),
7.807.85 (m, 2H, Ph). MS (EI, m/z, %): 323 (M+, 83). Anal. Calcd for C18H17N3O3: C, 66.86; H, 5.30; N,
13.00. Found: C, 66.56; H, 5.61; N, 12.77.
ACKNOWLEDGEMENTS
We thank the Slovenian Research Agency and the Ministry of Higher Education, Science and Technology
of Slovenia for financial support (P1-0230-0103).

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